{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:36:14Z","timestamp":1791005774563,"version":"4.1.0"},"reference-count":61,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2014,1,15]]},"abstract":"<jats:p> We tested the hypothesis that vascular endothelial function and oxidative stress are related to dietary niacin intake among healthy middle-aged and older adults. In 127 men and women aged 48\u201377 yr, brachial artery flow-mediated dilation (FMD) was positively related to dietary niacin intake [%change (\u0394): r = 0.20, P &lt; 0.05; mm\u0394: r = 0.25, P &lt; 0.01]. In subjects with above-average dietary niacin intake (\u226522 mg\/day, NHANES III), FMD was 25% greater than in subjects with below-average intake ( P &lt; 0.05). Stepwise linear regression revealed that dietary niacin intake (above vs. below average) was an independent predictor of FMD (%\u0394: \u03b2 = 1.8; mm\u0394: \u03b2 = 0.05, both P &lt; 0.05). Plasma oxidized low-density lipoprotein, a marker of systemic oxidative stress, was inversely related to niacin intake ( r = \u22120.23, P &lt; 0.05) and was lower in subjects with above- vs. below-average niacin intake (48 \u00b1 2 vs. 57 \u00b1 2 mg\/dl, P &lt; 0.01). Intravenous infusion of the antioxidant vitamin C improved brachial FMD in subjects with below-average niacin intake ( P &lt; 0.001, n = 33), but not above-average ( P &gt; 0.05, n = 20). In endothelial cells sampled from the brachial artery of a subgroup, dietary niacin intake was inversely related to nitrotyrosine, a marker of peroxynitrite-mediated oxidative damage ( r = \u22120.30, P &lt; 0.05, n = 55), and expression of the prooxidant enzyme, NADPH oxidase ( r = \u22120.44, P &lt; 0.01, n = 37), and these markers were lower in subjects with above- vs. below-average niacin intake [nitrotyrosine: 0.39 \u00b1 0.05 vs. 0.56 \u00b1 0.07; NADPH oxidase: 0.38 \u00b1 0.05 vs. 0.53 \u00b1 0.05 (ratio to human umbilical vein endothelial cell control), both P &lt; 0.05]. Our findings support the hypothesis that higher dietary niacin intake is associated with greater vascular endothelial function related to lower systemic and vascular oxidative stress among healthy middle-aged and older adults. <\/jats:p>","DOI":"10.1152\/japplphysiol.00969.2013","type":"journal-article","created":{"date-parts":[[2013,12,6]],"date-time":"2013-12-06T04:13:21Z","timestamp":1386303201000},"page":"156-163","source":"Crossref","is-referenced-by-count":40,"title":["Vascular endothelial function and oxidative stress are related to dietary niacin intake among healthy middle-aged and older adults"],"prefix":"10.1152","volume":"116","author":[{"given":"Rachelle E.","family":"Kaplon","sequence":"first","affiliation":[{"name":"Department of Integrative Physiology, University of Colorado, Boulder, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey B.","family":"Gano","sequence":"additional","affiliation":[{"name":"Department of Integrative Physiology, 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