{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:09:43Z","timestamp":1773421783685,"version":"3.50.1"},"reference-count":44,"publisher":"American Physiological Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2013,12,15]]},"abstract":"<jats:p>In neonatal rodents, a loss of brain stem serotonin [5-hydroxytryptamine (5-HT)] in utero or at birth compromises anoxia-induced gasping and the recovery of heart rate (HR) and breathing with reoxygenation (i.e., autoresuscitation). How mean arterial pressure (MAP) is influenced after an acute loss of brain stem 5-HT content is unknown. We hypothesized that a loss of 5-HT for \u223c1 day would compromise MAP during episodic anoxia. We injected 6-fluorotryptophan (20 mg\/kg ip) into rat pups (postnatal days 9\u201310 or 11\u201313, n = 22 treated, 24 control), causing a \u223c70% loss of brain stem 5-HT. Pups were exposed to a maximum of 15 anoxic episodes, separated by 5 min of room air to allow autoresuscitation. In younger pups, we measured breathing frequency and tidal volume using \u201chead-out\u201d plethysmography and HR from the electrocardiogram. In older pups, we used whole body plethysmography to detect gasping, while monitoring MAP. Gasp latency and the time required for respiratory, HR, and MAP recovery following each episode were determined. Despite normal gasp latency, breathing frequency and a larger tidal volume ( P &lt; 0.001), 5-HT-deficient pups survived one-half the number of episodes as controls ( P &lt; 0.001). The anoxia-induced decrease in MAP experienced by 5-HT-deficient pups was double that of controls ( P = 0.017), despite the same drop in HR ( P = 0.48). MAP recovery was delayed \u223c10 s by 5-HT deficiency ( P = 0.001). Our data suggest a loss of brain stem 5-HT leads to a pronounced, premature loss of MAP in response to episodic anoxia. These data may help explain why some sudden infant death syndrome cases die from what appears to be cardiovascular collapse during apparent severe hypoxia.<\/jats:p>","DOI":"10.1152\/japplphysiol.00970.2013","type":"journal-article","created":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T02:24:39Z","timestamp":1382063079000},"page":"1733-1741","source":"Crossref","is-referenced-by-count":19,"title":["Brain stem serotonin protects blood pressure in neonatal rats exposed to episodic anoxia"],"prefix":"10.1152","volume":"115","author":[{"given":"Hsiao T.","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, University of Missouri, Columbia, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin J.","family":"Cummings","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Missouri, Columbia, 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