{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T17:32:02Z","timestamp":1778607122225,"version":"3.51.4"},"reference-count":36,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2018,9,1]]},"abstract":"<jats:p> The physiological relevance of slow-wave vasomotion is still unclear, even though it has been hypothesized that it could be a compensatory mechanism for enhancing tissue oxygenation in conditions of reduced oxygen supply. The aim of our study was to explore the effects of hypoxia and ischemia on slow-wave vasomotion in microcirculation. Peripheral oxygen saturation and forearm microcirculation flow (laser-Doppler flowmetry) were recorded at baseline and during postocclusive reactive hyperemia in the Himalaya region from 8 European lowlanders (6 men; aged 29\u201339 yr) at 1,350, 3,400, and 5,050 m and from 10 Nepalese male highlanders (aged 21\u201339 yr) at 3,400 and 5,050 m of altitude. The same measurements were also performed at sea level in 16 healthy volunteers (aged 23\u201361 yr) during a short-term exposure to normobaric hypoxia. In lowlanders, exposure to progressively higher altitude under baseline flow conditions progressively increased 0.06\u20130.15 Hz vasomotion amplitude [power spectral density % was expressed as geometric means (geometric standard deviation)\u2009=\u200914.0 (3.6) at 1,350 m; 87.0(2.3) at 3,400 m and 249.8 (3.6) at 5,050 m; P\u2009= 0.006 and P\u2009&lt; 0.001 vs. 1,350 m, respectively]. In highlanders, low frequency vasomotion amplitude was similarly enhanced at different altitudes [power spectral density %\u2009=\u2009183.4 (4.1) at 3,400 m vs. 236.0 (3.0) at 5,050 m; P = 0.139]. In both groups at altitude, it was further increased after ischemic stimulus ( P\u2009&lt; 0.001). At baseline, acute short lasting normobaric hypoxia did not induce low frequency vasomotion, which was conversely induced by ischemia, even under normal oxygenation and barometric pressure. This study offers the demonstration of a significant increase in slow-wave vasomotion under prolonged hypobaric-hypoxia exposure at high altitude, with a further enhancement after ischemia induction. <\/jats:p><jats:p> NEW &amp; NOTEWORTHY This study offers the demonstration in humans of the occurrence of enhanced slow-wave vasomotion in microcirculation induced by exposure to hypobaric hypoxia, ischemia, and their combination. This phenomenon, where vasomotion can be hypothesized to behave as a \u201cperipheral heart,\u201d may represent a compensating adaptive change aimed at improving peripheral flow and tissue oxygenation in conditions of reduced oxygen supply, such as altitude-induced hypobaric hypoxia and postocclusion ischemia. <\/jats:p>","DOI":"10.1152\/japplphysiol.00977.2017","type":"journal-article","created":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T14:43:44Z","timestamp":1529592224000},"page":"780-789","source":"Crossref","is-referenced-by-count":20,"title":["Increase in slow-wave vasomotion by hypoxia and ischemia in lowlanders and highlanders"],"prefix":"10.1152","volume":"125","author":[{"given":"Paolo","family":"Salvi","sequence":"first","affiliation":[{"name":"Istituto Auxologico Italiano, Istituti di Ricovero e Cura a Carattere Scientifico, Department of Cardiovascular, Neural, and Metabolic Sciences, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Faini","sequence":"additional","affiliation":[{"name":"Istituto Auxologico Italiano, Istituti di Ricovero e Cura a Carattere Scientifico, Department of Cardiovascular, Neural, and Metabolic Sciences, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8775-2605","authenticated-orcid":false,"given":"Paolo","family":"Castiglioni","sequence":"additional","affiliation":[{"name":"Istituti di Ricovero e Cura a Carattere Scientifico Fondazione Don Carlo Gnocchi, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fausto","family":"Brunacci","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, \u2018M. Bufalini\u2019 Hospital, Romagna Local Healthcare Unit, Cesena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Montaguti","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, \u2018M. Bufalini\u2019 Hospital, Romagna Local Healthcare Unit, Cesena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Severi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, \u2018M. Bufalini\u2019 Hospital, Romagna Local Healthcare Unit, Cesena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"Gautier","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Centre Hospitalier R\u00e9gional Universitaire de Nancy, Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enzo","family":"Pretolani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, \u2018M. Bufalini\u2019 Hospital, Romagna Local Healthcare Unit, Cesena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanase","family":"Benetos","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Centre Hospitalier R\u00e9gional Universitaire de Nancy, Nancy, France"},{"name":"INSERM U1117, Universit\u00e9 de Lorraine, Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Parati","sequence":"additional","affiliation":[{"name":"Istituto Auxologico Italiano, Istituti di Ricovero e Cura a Carattere Scientifico, Department of Cardiovascular, Neural, and Metabolic Sciences, Milan, Italy"},{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2828(89)90855-9"},{"key":"B2","volume-title":"Laser Doppler","author":"Belcaro G","year":"1994"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1109\/IEMBS.2007.4353892"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1042\/cs0950565"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1991.260.2.H362"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/0026-2862(90)90071-X"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1990.259.1.H190"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/BF00583602"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00970.2016"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.2.359"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1995.269.2.H656"},{"key":"B12","first-page":"255","volume":"12","author":"Hoffmann U","year":"1993","journal-title":"Int J Microcirc Clin Exp"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/0026-2862(90)90028-P"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1177\/1358836X9000100202"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2006.05.006"},{"key":"B16","first-page":"19","volume":"4","author":"Lindbom L","year":"1985","journal-title":"Int J Microcirc Clin Exp"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod63.5.1383"},{"key":"B18","volume-title":"Digital Spectral Analysis with Applications","author":"Marple SL","year":"1987"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2009.051656"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-009-1023-8"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1987.253.3.H568"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.605527"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1124\/mi.3.2.79"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu275"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.25.6.1276"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2010.02198.x"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1024582"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.67.1.291"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2007.02.006"},{"key":"B30","volume-title":"Periodic Hemodynamics in Health and Disease","author":"Schmidt J","year":"1996"},{"key":"B31","first-page":"287","volume":"12","author":"Schmidt JA","year":"1993","journal-title":"Int J Microcirc Clin Exp"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.73.3.1077"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(02)02110-0"},{"key":"B34","first-page":"223","volume":"7","author":"Seifert H","year":"1988","journal-title":"Int J Microcirc Clin Exp"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1109\/10.790500"},{"key":"B36","first-page":"75","volume":"12","author":"Tsai AG","year":"1993","journal-title":"Int J Microcirc Clin Exp"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00977.2017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:10:36Z","timestamp":1567987836000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/japplphysiol.00977.2017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,1]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,9,1]]}},"alternative-id":["10.1152\/japplphysiol.00977.2017"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00977.2017","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,1]]}}}