{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T17:28:10Z","timestamp":1781890090240,"version":"3.54.5"},"reference-count":19,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:p> Exposing newborn rats to postnatal hyperoxia (60% O<jats:sub>2<\/jats:sub>) for 1-4 wk attenuates the ventilatory and phrenic nerve responses to acute hypoxia in adult rats. The goal of this research was to increase our understanding of the carotid chemoreceptor afferent neural input in this depressed response with different durations of postnatal hyperoxic exposure. Rats were exposed from a few days before birth to 1, 2, or 4 wk of 60% O<jats:sub>2<\/jats:sub> and studied after 3-5 mo in normoxia. The rats were anesthetized with urethane. Whole carotid sinus nerve (CSN) responses to NaCN (40 \u03bcg\/kg iv), 10 s of asphyxia and acute isocapnic hypoxia (arterial Po<jats:sub>2<\/jats:sub> 45 Torr) were determined. Mean CSN responses to stimuli after postnatal hyperoxia were reduced compared with controls. Responses in rats exposed to 1 wk of postnatal hyperoxia were less affected than those exposed to 2 and 4 wk of hyperoxia, which were equivalent to each other. These studies illustrate the importance of normoxia during the first 2 wk of life in development of carotid chemoreceptor afferent function. <\/jats:p>","DOI":"10.1152\/japplphysiol.00985.2002","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T15:46:24Z","timestamp":1425397584000},"page":"946-952","source":"Crossref","is-referenced-by-count":76,"title":["Adult carotid chemoafferent responses to hypoxia after 1, 2, and 4 wk of  postnatal hyperoxia"],"prefix":"10.1152","volume":"95","author":[{"given":"G. E.","family":"Bisgard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"E. B.","family":"Olson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.-Y.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. W.","family":"Bavis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. D.","family":"Fuller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. S.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"REF1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1999.276.5.L875"},{"key":"REF2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00859.2001"},{"key":"REF3","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0527hyp"},{"key":"REF4","unstructured":"Eden GJ and  Hanson MA. Effect of hyperoxia from birth on the carotid chemoreceptor and  ventilatory responses of rats to acute hypoxia (Abstract). 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In: Chemoreception: From Cellular Signalling to  Functional Plasticity, edited by Pequignot JM, Gonzalez C, Nurse  C, Dalmaz Y, and N Prabhakar N. London: Kluwer Academic\/Plenum. 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