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The output of VIP from the gland was frequency dependent over the range of 10-20 Hz (continuously) and significantly increased after atropine ( P &lt; 0.02). Furthermore, the fall in vascular resistance was linearly related to log VIP output after total muscarinic blockade. Intracarotid infusions of synthetic VIP produced dose-dependent falls in submandibular vascular resistance, together with a corresponding increase in submandibular blood flow. It is concluded that the atropine-resistant vasodilatation that occurs in this gland during parasympathetic stimulation is likely to be due largely, if not entirely, to the release of VIP.<\/jats:p>","DOI":"10.1152\/japplphysiol.00991.2002","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:46:54Z","timestamp":1425415614000},"page":"1598-1605","source":"Crossref","is-referenced-by-count":6,"title":["Submandibular responses to stimulation of the parasympathetic innervation in anesthetized sheep"],"prefix":"10.1152","volume":"95","author":[{"given":"C. M. B.","family":"Edwards","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. P.","family":"Corkery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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