{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T10:19:56Z","timestamp":1725790796199},"reference-count":20,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:p>Submandibular vascular and secretory responses to parasympathetic chorda-lingual (C-L) stimulation were investigated in anesthetized sheep before, during, and after an intracarotid (ic) infusion of endothelin-1 (ET-1). Stimulation of the peripheral end of the C-L nerve at 4 and 8 Hz produced a frequency-dependent reduction in submandibular vascular resistance (SVR) associated with a frequency-dependent increase in submandibular blood flow, salivary flow, and Na<jats:sup>+<\/jats:sup>, K<jats:sup>+<\/jats:sup>, and protein output from the gland. During stimulation at 4 Hz, ic ET-1 significantly increased SVR ( P &lt; 0.01), without significantly affecting either the aortic blood pressure or heart rate. Submandibular blood flow (SBF) was reduced by 48 \u00b1 4% and the flow of saliva by 50 \u00b1 1%. The effect on blood and salivary flow persisted for at least 30 min after the infusion of ET-1. The reduction in SBF was associated with a diminution in the output of Na<jats:sup>+<\/jats:sup>,K<jats:sup>+<\/jats:sup>, and protein in the saliva ( P &lt; 0.01). These effects persisted for 30 min after the infusion of ET-1 had been discontinued and were linearly related to the flow of plasma throughout.<\/jats:p>","DOI":"10.1152\/japplphysiol.00992.2002","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:46:02Z","timestamp":1425415562000},"page":"751-757","source":"Crossref","is-referenced-by-count":11,"title":["Effects of prolonged reduction in blood flow on submandibular secretory function in anesthetized sheep"],"prefix":"10.1152","volume":"95","author":[{"given":"A. S.","family":"Thakor","sequence":"first","affiliation":[{"name":"Physiological Laboratory, University of Cambridge, Cambridge CB2 3EG, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. N.","family":"Brown","sequence":"additional","affiliation":[{"name":"Physiological Laboratory, University of Cambridge, Cambridge CB2 3EG, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. V.","family":"Edwards","sequence":"additional","affiliation":[{"name":"Physiological Laboratory, University of Cambridge, Cambridge CB2 3EG, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"REF1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1912.sp001520"},{"key":"REF2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1956.sp005500"},{"key":"REF3","doi-asserted-by":"publisher","DOI":"10.1159\/000061091"},{"key":"REF4","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1997.sp004058"},{"key":"REF5","unstructured":"Edwards AVand Smaje LH.Nonadrenergic innervation of salivary gland blood vessels. In:Nonadrenergic Innervation of Blood Vessels, edited by Burnstock G and Griffith SG. Boca Raton, FL: CRC, 1988, vol.II, chapt. 10, p. 173-189."},{"key":"REF6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1955.tb01221.x"},{"key":"REF7","doi-asserted-by":"publisher","DOI":"10.1126\/science.2500708"},{"key":"REF8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-445X.1999.01871.x"},{"key":"REF9","doi-asserted-by":"publisher","DOI":"10.1016\/S1566-0702(02)00062-0"},{"key":"REF10","doi-asserted-by":"publisher","DOI":"10.1007\/BF01675814"},{"key":"REF11","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1878.sp000008"},{"key":"REF12","doi-asserted-by":"crossref","unstructured":"Langley JN.On the physiology of salivary secretion. Part V. The effect of stimulating the cerebral secretory nerves upon the amount of saliva obtained by stimulating the sympathetic nerve.J Physiol9: 291-328, 1889.","DOI":"10.1113\/jphysiol.1889.sp000305"},{"key":"REF13","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1990.sp018341"},{"key":"REF14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1998.275.2.G331"},{"key":"REF15","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1935.sp000679"},{"key":"REF16","doi-asserted-by":"publisher","DOI":"10.2170\/jjphysiol.13.541"},{"key":"REF17","doi-asserted-by":"publisher","DOI":"10.1159\/000061089"},{"key":"REF18","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.89.5.1964"},{"key":"REF19","doi-asserted-by":"crossref","unstructured":"Sreebny LM, Johnson DA, and Rabinovitch MR.Functional regulation of protein synthesis in the rat parotid gland.J Biol Chem246: 3879-3884, 1971.","DOI":"10.1016\/S0021-9258(18)62116-7"},{"key":"REF20","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-198812040-00024"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00992.2002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T09:46:40Z","timestamp":1651398400000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/japplphysiol.00992.2002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,8]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,8]]}},"alternative-id":["10.1152\/japplphysiol.00992.2002"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00992.2002","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,8]]}}}