{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:05:34Z","timestamp":1793822734300,"version":"4.6.1"},"reference-count":37,"publisher":"American Physiological Society","issue":"8","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI)","doi-asserted-by":"publisher","award":["1U01HL117718-01"],"award-info":[{"award-number":["1U01HL117718-01"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI)","doi-asserted-by":"publisher","award":["1U01HL117718-01"],"award-info":[{"award-number":["1U01HL117718-01"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2016,4,15]]},"abstract":"<jats:p> Sickle cell disease (SCD) is the most common cause of stroke in childhood and results primarily from a mismatch of cerebral oxygen supply and demand rather than arterial obstruction. However, resting cerebral blood flow (CBF) has not been examined in the general African American population, in whom obesity, hypertension, cerebrovascular disease, and diminished cerebrovascular reserve capacity are common. To better understand the underlying physiological substrate upon which SCD is superimposed, we measured CBF in 32 young (age 28 \u00b1 10 yr), asymptomatic African American subjects with and without sickle cell trait ( n = 14). To characterize the effects of chronic anemia, in isolation of sickle hemoglobin we also studied a cohort of 13 subjects with thalassemia major ( n = 10), dyserythropoetic anemia ( n = 1), or spherocytosis ( n = 2). Blood was analyzed for complete blood count, hemoglobin electrophoresis, cell free hemoglobin, and lactate dehydrogenase. Multivariate regression analysis showed that oxygen content was the strongest predictor of CBF ( r<jats:sup>2<\/jats:sup> = 0.33, P &lt; 0.001). CBF declined rapidly in the second and third decades of life, but this drop was explained by reductions in cerebral gray matter. However, age effects persisted after correction for brain composition, possibly representing microvascular impairment. CBF was independent of viscosity, hemoglobin S%, and body mass index. Hyperoxia resulted in reduced CBF by 12.6% ( P = 0.0002), and CBF changes were proportional to baseline oxygen content ( r<jats:sup>2<\/jats:sup> = 0.16, P = 0.02). These data suggest that these hemoglobin subtypes do not alter the normal CBF regulation of the balance of oxygen supply and demand. <\/jats:p>","DOI":"10.1152\/japplphysiol.00994.2015","type":"journal-article","created":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T21:55:14Z","timestamp":1453413314000},"page":"976-981","source":"Crossref","is-referenced-by-count":47,"title":["Predictors of cerebral blood flow in patients with and without anemia"],"prefix":"10.1152","volume":"120","author":[{"given":"Matthew T.","family":"Borzage","sequence":"first","affiliation":[{"name":"Division of Neonatology and Radiology, Children's Hospital Los Angeles, Los Angeles, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Bush","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Southern California, Los Angeles, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soyoung","family":"Choi","sequence":"additional","affiliation":[{"name":"Neuroscience Graduate Program, University of Southern California, Los Angeles, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aart J.","family":"Nederveen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"V\u00e1clav\u016f","sequence":"additional","affiliation":[{"name":"Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas D.","family":"Coates","sequence":"additional","affiliation":[{"name":"Division of Hematology, Children's Hospital Los Angeles, Los Angeles, California; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Wood","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Radiology, Children's Hospital Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807023390102"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20574"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200110000-00001"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103129"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-06-293514"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-012-0490-6"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92145-2"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/108.1.81"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600319"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-02-272682"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-05-349621"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410040410"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000043500.03647.81"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22242"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.12.2656"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3430-11.2012"},{"key":"B17","volume-title":"Design principles of the human brain: an evolutionary perspective. 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