{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:55:45Z","timestamp":1773420945468,"version":"3.50.1"},"reference-count":16,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:p> Hyperoxia in the immediate perinatal period, but not in adult life, is associated with a life-long impairment of the ventilatory response to acute hypoxia. This effect is attributed to a functional impairment of peripheral chemoreceptors, including a reduction in the number of chemoreceptor afferent fibers and a reduction in \u201cwhole nerve\u201d afferent activity. The purpose of the present study was to assess the activity levels of single chemoreceptor units in the immediate posthyperoxic period to determine whether functional impairment extended to single chemoreceptor units and whether the impairment was only induced by hyperoxia exposure in the immediate postnatal period. Two groups of rat pups were exposed to 60% inspired O<jats:sub>2<\/jats:sub> fraction for 2 wk at ages 0\u201314 days and 14\u201328 days, at which time single-unit activities were isolated and recorded in vitro. Compared with control pups, hyperoxia-treated pups had a 10-fold reduction in baseline (normoxia) spiking activity. Peak unit responses to 12, 5, and 0% O<jats:sub>2<\/jats:sub> were reduced and nerve conduction time was significantly slower in both hyperoxia-treated groups compared with control groups. We conclude that 1) hyperoxia greatly reduces single-unit chemoreceptor activities during normoxia and acute hypoxia, 2) the treatment effect is not limited to the immediate newborn period, and 3) at least part of the impairment may be due to changes in the afferent axonal excitability. <\/jats:p>","DOI":"10.1152\/japplphysiol.01009.2004","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T20:32:26Z","timestamp":1109277146000},"page":"114-119","source":"Crossref","is-referenced-by-count":39,"title":["Perinatal hyperoxia for 14 days increases nerve conduction time and the acute unitary response to hypoxia of rat carotid body chemoreceptors"],"prefix":"10.1152","volume":"99","author":[{"given":"David F.","family":"Donnelly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Insook","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Carle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John L.","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00859.2001"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01043.2002"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00985.2002"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0527hyp"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.301bi.x"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.88.4.1489"},{"key":"R7","unstructured":"Eden GJ and Hanson MA. Effect of hyperoxia from birth on the carotid chemoreceptor and ventilatory responses of rats to acute hypoxia (Abstract). J Physiol 374: 24P, 1986."},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.519bn.x"},{"key":"R9","unstructured":"Hanson MA, Eden GJ, Nijhuis JG, and Moore PJ. Peripheral chemoreceptors and other oxygen sensors in the feteus and newborn. In: Chemoreceptors and Reflexes in Breathing: Cellular and Molecular Aspects, edited by Lahiri S, Forster RE, Davies RO, and Pack AI. New York: Oxford University Press, 1989, p. 113\u2013120."},{"key":"R10","unstructured":"Kim I, Boyle KM, Carle CM, Donnelly DF, and Carroll JL. Perinatal hyperoxia reduces the depolarization and calcium increases in response to an acute hypoxia challenge in rat carotid chemoreceptor cells (Abstract). 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