{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T01:11:46Z","timestamp":1770772306504,"version":"3.50.0"},"reference-count":52,"publisher":"American Physiological Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2014,5,1]]},"abstract":"<jats:p>Patients with McArdle's disease (McA) typically show the \u201csecond-wind\u201d phenomenon, a sudden decrease in heart rate (HR) and an improved exercise tolerance occurring after a few minutes of exercise. In the present study, we investigated whether in McA a first bout of exercise determines a second wind during a second bout, separated by the first by a few minutes of recovery. Eight McA (44 \u00b1 4 yr) and a control group of six mitochondrial myopathy patients (51 \u00b1 6 yr) performed two repetitions (CWR1 and CWR2) of 6-min constant work rate exercise (\u223c50% of peak work rate) separated by 6-min (SHORT) or 18-min (LONG) recovery. Pulmonary O<jats:sub>2<\/jats:sub>uptake (V\u0307o<jats:sub>2<\/jats:sub>), HR, cardiac output, rates of perceived exertion, vastus lateralis oxygenation {changes in deoxygenated Hb and myoglobin Mb concentrations, \u0394[deoxy(Hb+Mb)], by near-infrared spectroscopy} were determined. In McA, V\u0307o<jats:sub>2<\/jats:sub>(0.86 \u00b1 0.2 vs. 0.95 \u00b1 0.1 l\/min), HR (113 \u00b1 10 vs. 150 \u00b1 13 beats\/min), cardiac output (11.6 \u00b1 0.6 vs. 15.0 \u00b1 0.8 l\/min), and rates of perceived exertion (11 \u00b1 2 vs. 14 \u00b1 3) were lower, whereas \u0394[deoxy(Hb+Mb)] was higher (14.7 \u00b1 2.3 vs. \u22120.1 \u00b1 4.6%) in CWR2-SHORT vs. CWR1; the \u201covershoot\u201d of \u0394[deoxy(Hb+Mb)] and the \u201cslow component\u201d of V\u0307o<jats:sub>2<\/jats:sub>kinetics disappeared in CWR2-SHORT. No differences (vs. CWR1) were observed in McA during CWR2-LONG, or in mitochondrial myopathy patients during both CWR2-SHORT and -LONG. A second-wind phenomenon was observed in McA during the second of two consecutive 6-min constant-work rate submaximal exercises. The second wind was associated with changes of physiological variables, suggesting an enhanced skeletal muscle oxidative metabolism. The second wind was not described after a longer (18-min) recovery period.<\/jats:p>","DOI":"10.1152\/japplphysiol.01063.2013","type":"journal-article","created":{"date-parts":[[2014,3,21]],"date-time":"2014-03-21T05:03:25Z","timestamp":1395378205000},"page":"1230-1237","source":"Crossref","is-referenced-by-count":22,"title":["The \u201csecond wind\u201d in McArdle's disease patients during a second bout of constant work rate submaximal exercise"],"prefix":"10.1152","volume":"116","author":[{"given":"Simone","family":"Porcelli","sequence":"first","affiliation":[{"name":"Institute of Bioimaging and Molecular Physiology, National Research Council, Segrate, Italy;"},{"name":"Department of Medical and Biological Sciences, University of Udine, Udine, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Marzorati","sequence":"additional","affiliation":[{"name":"Institute of Bioimaging and Molecular Physiology, National Research Council, Segrate, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Belletti","sequence":"additional","affiliation":[{"name":"Institute of Bioimaging and Molecular Physiology, National Research Council, Segrate, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Bellistri","sequence":"additional","affiliation":[{"name":"Institute of Bioimaging and Molecular Physiology, National Research Council, Segrate, Italy;"},{"name":"Department of Biomedical Sciences for Health, University of Milan, Milano, Italy; 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