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Here, we report for the first time that coingestion of a ketone monoester before and during prolonged cycling reduces blood glucose concentrations, exogenous CHO oxidation, and oxidation efficiency compared with CHO alone (120 g\u00b7h\n                    <jats:sup>\u22121<\/jats:sup>\n                    ; 1:0.8 ratio of maltodextrin and fructose). Ketone monoester ingestion also increased plasma abundance of metabolites associated with carbohydrate metabolism (glucaric acid) and protein turnover (3-methylhistidine).\n                  <\/jats:p>","DOI":"10.1152\/japplphysiol.01072.2025","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:51:12Z","timestamp":1775868672000},"page":"1373-1388","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Ketone monoester reduces blood glucose, exogenous CHO oxidation, and oxidation efficiency in trained male cyclists when fed 120 g\/h of CHO during exercise"],"prefix":"10.1152","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7686-2008","authenticated-orcid":false,"given":"Henry J.","family":"Martyn","sequence":"first","affiliation":[{"name":"Research Institute for Sport and Exercise Sciences (RISES), Liverpool John Moores University","place":["United 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