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Aggregation to ADP (10 \u03bcM) and collagen (6 \u03bcg\/ml) and ATP secretion to 50 nM thrombin were determined by turbidimetric analysis and bioluminescence, respectively. Total platelet counts, platelet turnover, and mean platelet volume did not change with maturity. Platelet aggregation and ATP secretion decreased in females but increased in males with maturity, whereas total ATP content remained unchanged in platelets from females but increased in platelets from males. Platelet fibrinogen receptor, P-selectin expression, and receptors for sex steroids did not change with sexual maturation. Plasma C-reactive protein and brain-type natriuretic peptide also did not change. Results indicate that changes in platelet aggregation and secretion change with sexual maturity differently in females and males. These observations provide evidence on which clinical studies could be designed to examine platelet characteristics in human children and young adults.<\/jats:p>","DOI":"10.1152\/japplphysiol.01074.2003","type":"journal-article","created":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:53:29Z","timestamp":1086051209000},"page":"1445-1452","source":"Crossref","is-referenced-by-count":37,"title":["Sex-specific changes in platelet aggregation and secretion with sexual maturity in pigs"],"prefix":"10.1152","volume":"97","author":[{"given":"Muthuvel","family":"Jayachandran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroya","family":"Okano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritu","family":"Chatrath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Whyte G.","family":"Owen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph P.","family":"McConnell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia M.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1648173"},{"key":"R3","unstructured":"Andrew M, David M, Adams M, Ali K, Anderson R, Barnard D, Bernstein M, Brisson L, Cairney B, and DeSai D.Venous thromboembolic complications (VTE) in children: first analyses of the Canadian Registry of VTE.Blood83: 1251\u20131257, 1994."},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb38785.x"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1614089"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199807000-00002"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1997.273.5.H2325"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1996.271.5.H1999"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00133.2002"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00099.2003"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00029.2003"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)01156-6"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.2527\/jas1982.542320x"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-0760(00)00037-6"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112606"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(05)70006-7"},{"key":"R17","unstructured":"Hutchinson WL, Koenig W, Frohlich M, Sund M, Lowe GDO, and Pepys MB.Immunoradiometric assay of circulating C-reactive protein: age-related values in the adult general population.Clin Chem46: 934\u2013938, 2000."},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00950.2001"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00958.2002"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1977.232.4.H381"},{"key":"R22","unstructured":"Khetawat G, Faraday N, Nealen ML, Vijayan KV, Bolton E, Noga SJ, and Bray PF.Human megakaryocytes and platelets contain the estrogen receptor \u03b2 and androgen receptor (AR): testosterone regulates AR expression.Blood95: 2289\u20132296, 2000."},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.5.3748"},{"key":"R24","doi-asserted-by":"crossref","unstructured":"McConnell JP, Branum EL, Ballman KV, Lagerstedt SA, Katzmann JA, and Jaffe AS.Gender differences in C-reactive protein concentrations. 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