{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:58:09Z","timestamp":1777615089790,"version":"3.51.4"},"reference-count":42,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:p> The objective of the present study was to examine the effects of preexercise NaHCO<jats:sub>3<\/jats:sub> administration to induce metabolic alkalosis on the arterial oxygenation in racehorses performing maximal exercise. Two sets of experiments, intravenous physiological saline and NaHCO<jats:sub>3<\/jats:sub> (250 mg\/kg iv), were carried out on 13 healthy, sound Thoroughbred horses in random order, 7 days apart. Blood-gas variables were examined at rest and during incremental exercise, leading to 120 s of galloping at 14 m\/s on a 3.5% uphill grade, which elicited maximal heart rate and induced pulmonary hemorrhage in all horses in both treatments. NaHCO<jats:sub>3<\/jats:sub> administration caused alkalosis and hemodilution in standing horses, but arterial O<jats:sub>2<\/jats:sub> tension and hemoglobin-O<jats:sub>2<\/jats:sub> saturation were unaffected. Thus NaHCO<jats:sub>3<\/jats:sub> administration caused a reduction in arterial O<jats:sub>2<\/jats:sub> content at rest, although the arterial-to-mixed venous blood O<jats:sub>2<\/jats:sub> content gradient was unaffected. During maximal exercise in both treatments, arterial hypoxemia, desaturation, hypercapnia, acidosis, hyperthermia, and hemoconcentration developed. Although the extent of exercise-induced arterial hypoxemia was similar, there was an attenuation of the desaturation of arterial hemoglobin in the NaHCO<jats:sub>3<\/jats:sub>-treated horses, which had higher arterial pH. Despite these observations, the arterial blood O<jats:sub>2<\/jats:sub> content of exercising horses was less in the NaHCO<jats:sub>3<\/jats:sub> experiments because of the hemodilution, and an attenuation of the exercise-induced expansion of the arterial-to-mixed venous blood O<jats:sub>2<\/jats:sub> content gradient was observed. It was concluded that preexercise NaHCO<jats:sub>3<\/jats:sub> administration does not affect the development and\/or severity of arterial hypoxemia in Thoroughbreds performing short-term, high-intensity exercise. <\/jats:p>","DOI":"10.1152\/japplphysiol.01083.2003","type":"journal-article","created":{"date-parts":[[2004,3,11]],"date-time":"2004-03-11T02:23:19Z","timestamp":1078971799000},"page":"1349-1356","source":"Crossref","is-referenced-by-count":16,"title":["NaHCO<sub>3<\/sub> does not affect arterial O<sub>2<\/sub> tension but attenuates desaturation of hemoglobin in maximally exercising Thoroughbreds"],"prefix":"10.1152","volume":"96","author":[{"given":"Murli","family":"Manohar","sequence":"first","affiliation":[{"name":"Departments of Veterinary Biosciences and Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas E.","family":"Goetz","sequence":"additional","affiliation":[{"name":"Departments of Veterinary Biosciences and Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aslam S.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Departments of Veterinary Biosciences and Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"REF1","doi-asserted-by":"crossref","unstructured":"Beard LA and Hinchcliff KW. 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