{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:36:52Z","timestamp":1791398212384,"version":"4.3.3"},"reference-count":59,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:p>Pain is a cardinal symptom in musculoskeletal diseases involving the knee joint, and aberrant movement patterns and motor control strategies are often present in these patients. However, the underlying neuromuscular mechanisms linking pain to movement and motor control are unclear. To investigate the functional significance of muscle pain on knee joint control during walking, three-dimensional gait analyses were performed before, during, and after experimentally induced muscle pain by means of intramuscular injections of hypertonic saline (5.8%) into vastus medialis (VM) muscle of 20 healthy subjects. Isotonic saline (0.9%) was used as control. Surface electromyography (EMG) recordings of VM, vastus lateralis (VL), biceps femoris, and semitendinosus muscles were synchronized with the gait analyses. During experimental muscle pain, the loading response phase peak knee extensor moments were attenuated, and EMG activity in the VM and VL muscles was reduced. Compressive forces, adduction moments, knee joint kinematics, and hamstring EMG activity were unaffected by pain. Interestingly, the observed changes persisted when the pain had vanished. The results demonstrate that muscle pain modulated the function of the quadriceps muscle, resulting in impaired knee joint control and joint instability during walking. The changes are similar to those observed in patients with knee pain. The loss of joint control during and after pain may leave the knee joint prone to injury and potentially participate in the chronicity of musculoskeletal problems, and it may have clinically important implications for rehabilitation and training of patients with knee pain of musculoskeletal origin.<\/jats:p>","DOI":"10.1152\/japplphysiol.01105.2006","type":"journal-article","created":{"date-parts":[[2007,4,6]],"date-time":"2007-04-06T00:39:58Z","timestamp":1175819998000},"page":"132-139","source":"Crossref","is-referenced-by-count":89,"title":["Experimental quadriceps muscle pain impairs knee joint control during walking"],"prefix":"10.1152","volume":"103","author":[{"given":"Marius","family":"Henriksen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tine","family":"Alkj\u00e6r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Lund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik B.","family":"Simonsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Graven-Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bente","family":"Danneskiold-Sams\u00f8e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Bliddal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-002-0787-x"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1023\/B:ABME.0000017541.82498.37"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-005-0005-6"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.026526"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(03)00061-9"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-003-1026-9"},{"key":"R7","unstructured":"Creamer P, Lethbridge-Cejku M, Hochberg MC.Determinants of pain severity in knee osteoarthritis: effect of demographic and psychosocial variables using 3 pain measures.J Rheumatol26: 1785\u20131792, 1999."},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.5.490"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1097\/00042752-200104000-00007"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199810000-00003"},{"key":"R11","unstructured":"Dieppe PA.Relationship between symptoms and structural change in osteoarthritis. what are the important targets for osteoarthritis therapy?J Rheumatol Suppl70: 50\u201353, 2004."},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100050409"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-005-2244-7"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-004-1083-8"},{"key":"R15","doi-asserted-by":"crossref","unstructured":"Fisher NM, Pendergast DR.Reduced muscle function in patients with osteoarthritis.Scand J Rehabil Med29: 213\u2013221, 1997.","DOI":"10.2340\/165019771997213221"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.3109\/09638289709166827"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9290(03)00189-1"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9290(03)00190-8"},{"key":"R19","unstructured":"Graven-Nielsen T.Sensory Manifestations and Sensory-Motor Interactions During Experimental Muscle Pain in Man(Dissertation). Aalborg, Denmark: Center for Sensory-Motor Interaction, Aalborg University, 1997."},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(96)03243-5"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10225"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-980X(96)96554-6"},{"key":"R23","doi-asserted-by":"crossref","unstructured":"Graven-Nielsen T.Fundamentals of muscle pain, referred pain, and deep tissue hyperalgesia.Scand J Rheumatol35: 1\u201343, 2006.","DOI":"10.1080\/03009740600865980"},{"key":"R24","doi-asserted-by":"crossref","unstructured":"Hodges PW, Bui BH.A comparison of computer-based methods for the determination of onset of muscle contraction using electromyography.Electroencephalogr Clin Neurophysiol101: 511\u2013519, 1996.","DOI":"10.1016\/S0013-4694(96)95190-5"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiomech.2004.08.004"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70068-5"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(01)00081-X"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100180409"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9290(01)00036-7"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1016\/0141-5425(85)90055-X"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(87)90295-8"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1139\/y91-102"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197860050-00014"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1136\/ard.52.4.258"},{"key":"R35","unstructured":"O'Reilly S, Doherty M.Signs, symptoms, and laboratory tests. In:Osteoarthritis, edited by Brandt KD, Doherty M, and Lohmander LS. Oxford, UK: Oxford University Press, 2003, p. 197\u2013210."},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(86)90162-4"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(02)00162-8"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197961030-00015"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/77.10.1063"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1002\/art.21357"},{"key":"R41","unstructured":"Riskowski JL, Mikesky AE, Bahamonde RE, Alvey TV 3rd, Burr DB.Proprioception, gait kinematics, and rate of loading during walking: are they related?J Musculoskelet Neuronal Interact5: 379\u2013387, 2005."},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100090114"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780360905"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2004.03.005"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.1985.tb00589.x"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70069-7"},{"key":"R47","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199705000-00013"},{"key":"R48","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400821"},{"key":"R49","doi-asserted-by":"crossref","unstructured":"Shrader MW, Draganich LF, Pottenger LA, Piotrowski GA.Effects of knee pain relief in osteoarthritis on gait and stair-stepping.Clin Orthop188\u2013193, 2004.","DOI":"10.1097\/01.blo.0000119248.70353.a5"},{"key":"R50","doi-asserted-by":"crossref","unstructured":"Simonsen EB, Dyhre-Poulsen P, Voigt M, Aagaard P, Fallentin N.Mechanisms contributing to different joint moments observed during human walking.Scand J Med Sci Sports7: 1\u201313, 1997.","DOI":"10.1111\/j.1600-0838.1997.tb00110.x"},{"key":"R51","doi-asserted-by":"publisher","DOI":"10.1016\/S1090-3801(02)00141-6"},{"key":"R52","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-127-2-199707150-00001"},{"key":"R53","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199811)41:11<1951::AID-ART9>3.0.CO;2-9"},{"key":"R54","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(02)00325-1"},{"key":"R55","doi-asserted-by":"publisher","DOI":"10.1054\/jpai.2001.19951"},{"key":"R56","doi-asserted-by":"publisher","DOI":"10.1016\/S0268-0033(99)00083-2"},{"key":"R57","unstructured":"Vaughan CL, Davis BL, O'Connor JC.Dynamics of Human Gait.Cape Town, South Africa: Kiboho, 1999."},{"key":"R58","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-6362(99)00041-7"},{"key":"R59","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(80)90162-1"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.01105.2006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T16:29:14Z","timestamp":1736958554000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/japplphysiol.01105.2006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["10.1152\/japplphysiol.01105.2006"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.01105.2006","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7]]}}}