{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T05:11:39Z","timestamp":1755925899705},"reference-count":27,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2002,12,1]]},"abstract":"<jats:p>Many avian species exhibit an extraordinary ability to exercise under hypoxic condition compared with mammals, and more efficient pulmonary O<jats:sub>2<\/jats:sub>transport has been hypothesized to contribute to this avian advantage. We studied six emus ( Dromaius novaehollandaie, 4\u20136 mo old, 25\u201340 kg) at rest and during treadmill exercise in normoxia and hypoxia (inspired O<jats:sub>2<\/jats:sub>fraction \u2248 0.13). The multiple inert gas elimination technique was used to measure ventilation-perfusion (V\u02d9\/Q\u02d9) distribution of the lung and calculate cardiac output and parabronchial ventilation. In both normoxia and hypoxia, exercise increased arterial Po<jats:sub>2<\/jats:sub>and decreased arterial Pco<jats:sub>2<\/jats:sub>, reflecting hyperventilation, whereas pH remained unchanged. The V\u02d9\/Q\u02d9 distribution was unimodal, with a log standard deviation of perfusion distribution = 0.60 \u00b1 0.06 at rest; this did not change significantly with either exercise or hypoxia. Intrapulmonary shunt was &lt;1% of the cardiac output in all conditions. CO<jats:sub>2<\/jats:sub>elimination was enhanced by hypoxia and exercise, but O<jats:sub>2<\/jats:sub>exchange was not affected by exercise in normoxia or hypoxia. The stability of V\u02d9\/Q\u02d9 matching under conditions of hypoxia and exercise may be advantageous for birds flying at altitude.<\/jats:p>","DOI":"10.1152\/japplphysiol.01108.2001","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:42:53Z","timestamp":1425415373000},"page":"1980-1986","source":"Crossref","is-referenced-by-count":17,"title":["Ventilation-perfusion inequality during normoxic and hypoxic exercise in the emu"],"prefix":"10.1152","volume":"93","author":[{"given":"P. M.","family":"Schmitt","sequence":"first","affiliation":[{"name":"White Mountain Research Station, University of California, San Diego, La Jolla, California 92093-0689"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. 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