{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:27:34Z","timestamp":1790396854738,"version":"4.1.0"},"reference-count":36,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2014,2,15]]},"abstract":"<jats:p> Pressure-volume loops describe dynamic ventricular performance, relevant to patients with and at risk of pulmonary hypertension. We used conductance catheter-derived pressure-volume loops to measure right ventricular (RV) mechanics in patients with chronic thromboembolic pulmonary arterial obstruction at different stages of pathological adaptation. Resting conductance catheterization was performed in 24 patients: 10 with chronic thromboembolic pulmonary hypertension (CTEPH), 7 with chronic thromboembolic disease without pulmonary hypertension (CTED), and 7 controls. To assess the validity of conductance measurements, RV volumes were compared in a subset of 8 patients with contemporaneous cardiac magnetic resonance (CMR). Control, CTED, and CTEPH groups showed different pressure-volume loop morphology, most notable during systolic ejection. Prolonged diastolic relaxation was seen in patients with CTED and CTEPH [tau = 56.2 \u00b1 6.7 (controls) vs. 69.7 \u00b1 10.0 (CTED) vs. 67.9 \u00b1 6.2 ms (CTEPH), P = 0.02]. Control and CTED groups had lower afterload (Ea) and contractility (Ees) compared with the CTEPH group (Ea = 0.30 \u00b1 0.10 vs. 0.52 \u00b1 0.24 vs. 1.92 \u00b1 0.70 mmHg\/ml, respectively, P &lt; 0.001) (Ees = 0.44 \u00b1 0.20 vs. 0.59 \u00b1 0.15 vs. 1.13 \u00b1 0.43 mmHg\/ml, P &lt; 0.01) with more efficient ventriculoarterial coupling (Ees\/Ea = 1.46 \u00b1 0.30 vs. 1.27 \u00b1 0.36 vs. 0.60 \u00b1 0.18, respectively, P &lt; 0.001). Stroke volume assessed by CMR and conductance showed closest agreement (mean bias +9 ml, 95% CI \u22121 to +19 ml) compared with end-diastolic volume (+48 ml, \u221216 to 111 ml) and end-systolic volume (+37 ml, \u221221 to 94 ml). RV conductance catheterization detects novel alteration in pressure-volume loop morphology and delayed RV relaxation in CTED, which distinguish this group from controls. The observed agreement in stroke volume assessed by CMR and conductance suggests RV mechanics are usefully measured by conductance catheter in chronic thromboembolic obstruction. <\/jats:p>","DOI":"10.1152\/japplphysiol.01123.2013","type":"journal-article","created":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T02:49:10Z","timestamp":1387507750000},"page":"355-363","source":"Crossref","is-referenced-by-count":100,"title":["Right ventricular dysfunction in chronic thromboembolic obstruction of the pulmonary artery: a pressure-volume study using the conductance catheter"],"prefix":"10.1152","volume":"116","author":[{"given":"Colm","family":"McCabe","sequence":"first","affiliation":[{"name":"Pulmonary Vascular Disease Unit, Papworth Hospital, Cambridge, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"White","sequence":"additional","affiliation":[{"name":"Medical Physics and Clinical Engineering Department, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom and Post Graduate Medical Institute, Anglia Ruskin University, Chelmsford, Essex, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen P.","family":"Hoole","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Papworth Hospital, Cambridge, United Kingdom; 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