{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T05:12:01Z","timestamp":1772601121897,"version":"3.50.1"},"reference-count":40,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["G12M6372"],"award-info":[{"award-number":["G12M6372"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Victorian Government's Operational Infrastructure Support Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2015,3,15]]},"abstract":"<jats:p> Experimentally, a typical \u223c2-min cord clamp-to-ventilation interval in preterm lambs is accompanied by increased hemodynamic lability of the birth transition. However, whether this lability is related to development of asphyxia after cord clamping, or can be avoided with a shorter clamp-to-ventilation interval, is unknown. To address these questions, anesthetized preterm fetal lambs (gestation 127 \u00b1 2 days) were instrumented with ductus arteriosus and left pulmonary artery flow probes to obtain right ventricular (RV) output, brachiocephalic trunk and aortic isthmus flow probes to measure left ventricular (LV) output, and aortic trunk catheters for pressure measurement and blood gas analysis. With hemodynamics recorded continuously, fetuses were delivered onto the ewe's abdomen and the cord clamped for 1.5 min before ventilation ( n = 8), with aortic sampling at 15, 30, 45, and 60 s, or for 0.5 min, with sampling at 15 s ( n = 4). With 1.5-min cord clamping, an asphyxial state (Po<jats:sub>2<\/jats:sub> &lt; 10 mmHg) was evident at \u226545 s, with bradycardia and marked falls in LV and RV outputs (by 60% and 50%, P &lt; 0.001), followed after ventilation onset by tachycardia and LV and RV output surges (4- and 3-fold, P &lt; 0.001). By contrast, heart rate and outputs remained stable after 0.5-min cord clamping, with no postventilation change in heart rate or RV output, and a lesser rise in LV output (22%, P &lt; 0.005). In preterm lambs, rapid development of an asphyxial state within 45 s in the cord clamp-to-ventilation interval increased hemodynamic lability of the birth transition, which was reduced with a shorter (\u223c0.5 min) cord clamp-to-ventilation interval. <\/jats:p>","DOI":"10.1152\/japplphysiol.01147.2014","type":"journal-article","created":{"date-parts":[[2015,1,23]],"date-time":"2015-01-23T00:17:07Z","timestamp":1421972227000},"page":"675-683","source":"Crossref","is-referenced-by-count":27,"title":["Onset of asphyxial state in nonrespiring interval between cord clamping and ventilation increases hemodynamic lability of birth transition in preterm lambs"],"prefix":"10.1152","volume":"118","author":[{"given":"Joseph J.","family":"Smolich","sequence":"first","affiliation":[{"name":"Heart Research Group, Murdoch Childrens Research Institute, Parkville, Australia;"},{"name":"Department of Paediatrics, University of Melbourne, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly R.","family":"Kenna","sequence":"additional","affiliation":[{"name":"Heart Research Group, Murdoch Childrens Research Institute, Parkville, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael M.","family":"Cheung","sequence":"additional","affiliation":[{"name":"Heart Research Group, Murdoch Childrens Research Institute, Parkville, Australia;"},{"name":"Department of Cardiology, Royal Children's Hospital, Parkville, Australia; 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