{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T05:44:00Z","timestamp":1698644640808},"reference-count":24,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:p>To understand the genetic basis of pathways involved in the control of breathing, a large scale, high-throughput study using chromosomal substitution strains of rats is underway. Eight new consomic rat stains (SS-2<jats:sup>BN<\/jats:sup>, SS-4<jats:sup>BN<\/jats:sup>, SS-6<jats:sup>BN<\/jats:sup>, SS-7<jats:sup>BN<\/jats:sup>, SS-8<jats:sup>BN<\/jats:sup>, SS-11<jats:sup>BN<\/jats:sup>, SS-12<jats:sup>BN<\/jats:sup>, SS-14<jats:sup>BN<\/jats:sup>, SS-Y<jats:sup>BN<\/jats:sup>), containing one homozygous BN\/NHsdMcwi (BN) chromosome on a background of SS\/JrHsdMcwi (SS), were created by PhysGen ( http:\/\/pga.mcw.edu ) Program for Genomic Applications. Male and female rats were studied using standard plethysmography under control conditions and during acute hypoxia (inspired oxygen fraction = 0.12) and hypercapnia (inspired CO<jats:sub>2<\/jats:sub>fraction = 0.07). The rats were also studied during treadmill exercise. Both male and female BN rats had a significantly lower ventilatory response during 7% CO<jats:sub>2<\/jats:sub>compared with SS rats of the same gender. SS-6<jats:sup>BN<\/jats:sup>female rats had a significantly reduced ventilatory response, similar to BN rats due primarily to a reduced tidal volume. Male SS-6<jats:sup>BN<\/jats:sup>rats had a significantly reduced tidal volume response to hypercapnia but a slightly increased frequency response during hypercapnia. Gene(s) on the Y chromosome may play a role in this increased frequency response in the male rats because the SS-Y<jats:sup>BN<\/jats:sup>hypercapnic ventilatory response involves a significantly increased frequency response. Several chromosomal substitutions slightly altered the ventilatory responses to hypoxia and exercise. However, genes on chromosomes 6 and Y of those studied are of primary importance in aspects of ventilatory control currently studied.<\/jats:p>","DOI":"10.1152\/japplphysiol.01148.2004","type":"journal-article","created":{"date-parts":[[2005,1,21]],"date-time":"2005-01-21T01:23:59Z","timestamp":1106270639000},"page":"1630-1638","source":"Crossref","is-referenced-by-count":14,"title":["Genetic determinants on rat chromosome 6 modulate variation in the hypercapnic ventilatory response using consomic strains"],"prefix":"10.1152","volume":"98","author":[{"given":"M. R.","family":"Dwinell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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