{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:52:44Z","timestamp":1791571964138,"version":"4.3.4"},"reference-count":45,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2014,3,1]]},"abstract":"<jats:p> Motor impairment in Parkinson's disease (PD) is partly due to defective central processing of lower limb afferents. Concomitant alterations in cardiovascular autonomic control leading to orthostatic hypotension may worsen motor ability. We evaluated whether mechanical activation of feet sensory afferents could improve gait and modify the response of cardiovascular autonomic control to stressors in 16 patients (age 66 \u00b1 2 yr) with idiopathic PD (Hoehn &amp; Yhar scale 2\u20133) on their usual therapy. Eight subjects ( group A) were randomized to undergo skin pressure (0.58 \u00b1 0.04 kg\/mm<jats:sup>2<\/jats:sup>) stimulation at the hallux tip and first metatarsal joint (effective stimulation; ES) of both feet. Eight remaining patients ( group B) underwent sham stimulation (SS) followed by ES. Three-dimensional movement analysis provided quantitative indexes of movement disability before (baseline) and 24 h after ES and SS. Spectral analysis of heart rate and blood pressure variability provided markers of cardiac sympatho-vagal (LF\/HF) and vascular sympathetic (LF<jats:sub>SAP<\/jats:sub>) modulations. Markers were measured at rest and during 75\u00b0 head-up tilt, before and 24 h after ES and SS. After ES, step length and gait velocity increased, upright rotation velocity was enhanced, and step number was decreased. After ES, LF<jats:sub>SAP<\/jats:sub> declined. The increase in LF\/HF and LF<jats:sub>SAP<\/jats:sub> induced by tilt was greater than before feet stimulation. No changes in gait and autonomic parameters were observed after SS. Twenty-four hours after ES, patients with PD showed improved gait and increased cardiac and vascular sympathetic modulation during upright position compared with baseline. Conversely, SS was ineffective on both movement and autonomic parameters, indicating a site specificity effect of the stimulation. <\/jats:p>","DOI":"10.1152\/japplphysiol.01160.2013","type":"journal-article","created":{"date-parts":[[2014,1,16]],"date-time":"2014-01-16T22:53:46Z","timestamp":1389912826000},"page":"495-503","source":"Crossref","is-referenced-by-count":41,"title":["Effects of mechanical stimulation of the feet on gait and cardiovascular autonomic control in Parkinson's disease"],"prefix":"10.1152","volume":"116","author":[{"given":"Franca","family":"Barbic","sequence":"first","affiliation":[{"name":"Internal Medicine, Humanitas Clinical and Research Center, Rozzano, University of Milan, Neuroscience Research Association, Milan, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Galli","sequence":"additional","affiliation":[{"name":"Department of Electronics Information and Bioengineering, Politecnico di Milano, Milan, 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