{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T15:39:51Z","timestamp":1776440391017,"version":"3.51.2"},"reference-count":39,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:p> The purpose of the present study was to test the hypothesis that administration of thyroid hormone [3,5,3\u2032-triiodo-l-thyronine (T<jats:sub>3<\/jats:sub>)] could result in oxidation of myofibrillar proteins and, in turn, induce alterations in respiratory muscle function. Daily injection of T<jats:sub>3<\/jats:sub> for 21 days depressed isometric forces of diaphragm fiber bundles across a range of stimulus frequencies (1, 10, 20, 40, 75, and 100 Hz) ( P &lt; 0.05). These reductions in force production were accompanied by a remarkable increment (104%; P &lt; 0.05) in carbonyl groups of myofibrillar proteins. In contrast, T<jats:sub>3<\/jats:sub> treatment has no effects on the carbonyl content in myosin heavy chain. In additional experiments, we have also tested the efficacy of carvedilol, a nonselective \u03b2<jats:sub>1<\/jats:sub>- \u03b2<jats:sub>2<\/jats:sub>-blocker that possesses antioxidative properties. Treatment with carvedilol dramatically improved isometric tetanic force production at stimulus frequencies from 40 to 100 Hz ( P &lt; 0.05). Carvedilol also prevented T<jats:sub>3<\/jats:sub>-induced contractile protein oxidation ( P &lt; 0.05). These data suggest that the oxidative modification of myofibrillar proteins may account, at least in part, for an impairment of diaphragm in hyperthyroidism. <\/jats:p>","DOI":"10.1152\/japplphysiol.01177.2006","type":"journal-article","created":{"date-parts":[[2007,2,16]],"date-time":"2007-02-16T01:47:23Z","timestamp":1171590443000},"page":"1850-1855","source":"Crossref","is-referenced-by-count":20,"title":["Myofibrillar protein oxidation and contractile dysfunction in hyperthyroid rat diaphragm"],"prefix":"10.1152","volume":"102","author":[{"given":"Takashi","family":"Yamada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Mishima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minako","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Matsunaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanobu","family":"Wada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.565bn.x"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0507fje"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1210\/endo-120-4-1417"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1210\/endo-121-6-2112"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(90)90077-V"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200407-887OC"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(98)00342-6"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.90.1.45"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00714.2003"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1007\/BF00712152"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2005.02.023"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1113\/eph8602109"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1042\/bj3240001"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1007\/s004240100587"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-870425"},{"key":"R17","doi-asserted-by":"crossref","unstructured":"Kahaly GJ, Nieswandt J, Wagner S, Schlegel J, Mohr-Kahaly S, Hommel G. 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