{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:16:57Z","timestamp":1773418617509,"version":"3.50.1"},"reference-count":26,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:p> We tested the hypothesis that local heating-induced nitric oxide (NO) production attenuates cutaneous vasoconstrictor responsiveness. Eleven subjects (6 men, 5 women) had four microdialysis membranes placed in forearm skin. Two membranes were perfused with 10 mM of N<jats:sup>G<\/jats:sup>-nitro-l-arginine (l-NAME) and two with Ringer solution (control), and all sites were locally heated to 34\u00b0C. Subjects then underwent 5 min of 60-mmHg lower body negative pressure (LBNP). Two sites (a control and an l-NAME site) were then heated to 39\u00b0C, while the other two sites were heated to 42\u00b0C. At the l-NAME sites, skin blood flow was elevated using 0.75\u20132 mg\/ml of adenosine in the perfusate solution (Adn + l-NAME) to a similar level relative to control sites. Subjects then underwent another 5 min of 60-mmHg LBNP. At 34\u00b0C, cutaneous vascular conductance (CVC) decreased (\u0394) similarly at both control and l-NAME sites during LBNP (\u03947.9 \u00b1 3.0 and \u03943.4 \u00b1 0.8% maximum, respectively; P &gt; 0.05). The reduction in CVC to LBNP was also similar between control and Adn + l-NAME sites at 39\u00b0C (control \u039411.4 \u00b1 2.5 vs. Adn + l-NAME \u03947.9 \u00b1 2.0% maximum; P &gt; 0.05) and 42\u00b0C (control \u03941.9 \u00b1 2.7 vs. Adn + l-NAME \u0394 4.2 \u00b1 2.7% maximum; P &gt; 0.05). However, the decrease in CVC at 42\u00b0C, regardless of site, was smaller than at 39\u00b0C ( P &lt; 0.05). These results do not support the hypothesis that local heating-induced NO production attenuates cutaneous vasoconstrictor responsiveness during high levels of LBNP. However, elevated local temperature, per se, attenuates cutaneous vasoconstrictor responsiveness to LBNP, presumably through non-nitric oxide mechanisms. <\/jats:p>","DOI":"10.1152\/japplphysiol.01181.2006","type":"journal-article","created":{"date-parts":[[2007,2,3]],"date-time":"2007-02-03T06:52:20Z","timestamp":1170485540000},"page":"1839-1843","source":"Crossref","is-referenced-by-count":17,"title":["Does local heating-induced nitric oxide production attenuate vasoconstrictor responsiveness to lower body negative pressure in human skin?"],"prefix":"10.1152","volume":"102","author":[{"given":"David A.","family":"Low","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Shibasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott L.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Keller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig G.","family":"Crandall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.54.5.547"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2001.280.5.R1494"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.90.3.1020"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.075747"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/3.3.211"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1976.41.6.826"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.1986.tb00239.x"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.66.5.1420"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.86.4.1185"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00826.2002"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00668.2003"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1990.68.3.1220"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1968.25.3.268"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1998.275.3.R844"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00029.2005"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.4.1619"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1969.27.5.673"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1973.34.5.639"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1984.57.1.191"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.60.5.1535"},{"key":"R21","doi-asserted-by":"crossref","unstructured":"Vanhoutte PM, Cooke JP, Lindblad LE, Shepherd JT, Flavahan NA. 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