{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:47:57Z","timestamp":1791290877358,"version":"4.3.0"},"reference-count":39,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:p> The influence of icing on muscle regeneration after crush injury was examined in the rat extensor digitorum longus. After the injury, animals were randomly divided into nonicing and icing groups. In the latter, ice packs were applied for 20 min. Due to the icing, degeneration of the necrotic muscle fibers and differentiation of satellite cells at early stages of regeneration were retarded by \u223c1 day. In the icing group, the ratio of regenerating fibers showing central nucleus at 14 days after the injury was higher, and cross-sectional area of the muscle fibers at 28 days was evidently smaller than in the nonicing group. Besides, the ratio of collagen fibers area at 14 and 28 days after the injury in the icing group was higher than in the nonicing group. These findings suggest that icing applied soon after the injury not only considerably retarded muscle regeneration but also induced impairment of muscle regeneration along with excessive collagen deposition. Macrophages were immunohistochemically demonstrated at the injury site during degeneration and early stages of regeneration. Due to icing, chronological changes in the number of macrophages and immunohistochemical expression of transforming growth factor (TGF)-\u03b21 and IGF-I were also retarded by 1 to 2 days. Since it has been said that macrophages play important roles not only for degeneration, but also for muscle regeneration, the influence of icing on macrophage activities might be closely related to a delay in muscle regeneration, impairment of muscle regeneration, and redundant collagen synthesis. <\/jats:p>","DOI":"10.1152\/japplphysiol.01187.2010","type":"journal-article","created":{"date-parts":[[2010,12,17]],"date-time":"2010-12-17T04:18:44Z","timestamp":1292559524000},"page":"382-388","source":"Crossref","is-referenced-by-count":103,"title":["Influence of icing on muscle regeneration after crush injury to skeletal muscles in rats"],"prefix":"10.1152","volume":"110","author":[{"given":"Ryo","family":"Takagi","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Sciences, Kobe University Graduate School of Health Sciences, Kobe; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences, Kobe University Graduate School of Health Sciences, Kobe; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamitsu","family":"Arakawa","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences, Kobe University Graduate School of Health Sciences, Kobe; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Kawada","sequence":"additional","affiliation":[{"name":"Department of Life Science, Graduate School of Arts and Science, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naokata","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Life Science, Graduate School of Arts and Science, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinori","family":"Miki","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences, Kobe University Graduate School of Health Sciences, Kobe; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00299406"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041380213"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1998.275.1.E118"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-200107000-00002"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006816123601"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/55.1.11"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(95)80066-2"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200212046"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041570213"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200209000-00009"},{"key":"B11","first-page":"589","volume":"54","author":"Dijkstra CD","year":"1985","journal-title":"Immunology"},{"key":"B12","first-page":"481","volume":"17","author":"Frorini JR","year":"1996","journal-title":"Endocr Rev"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000145887.48534.6f"},{"key":"B14","first-page":"91","volume":"26","author":"Furuta A","year":"2001","journal-title":"Med J Kinki Univ"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1177\/036354659602406S02"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9084(92)90121-T"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1998.00176.x"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.21.12100"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200205000-00022"},{"key":"B20","first-page":"88","volume":"39","author":"Hubbard TJ","year":"2004","journal-title":"J Athl Train"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1177\/0363546505274714"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1053\/jhsu.2002.34004"},{"key":"B23","first-page":"7","volume":"11","author":"Knight KL","year":"1976","journal-title":"Athl Train J Natl Athl Train Assoc"},{"key":"B24","volume-title":"Cryotherapy in Sport Injury Management","author":"Knight KL","year":"1995"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-198603060-00002"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199906)22:6<724::AID-MUS9>3.0.CO;2-O"},{"key":"B27","first-page":"209","volume":"37","author":"Merrick MA","year":"2002","journal-title":"J Athl Train"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.1988.9.9.301"},{"key":"B29","volume-title":"Thermal Physiology","author":"Nakayama A","year":"1981"},{"key":"B30","unstructured":"Nonaka S. 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