{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:49:21Z","timestamp":1787017761919,"version":"build-2736575974"},"reference-count":28,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:p>\n                    Increased intracranial pressure is suspected in the pathogenesis of acute mountain sickness (AMS), but no studies have correlated it with the presence or severity of AMS. We sought to determine whether increased optic nerve sheath diameter, a surrogate measure of intracranial pressure, is associated with the presence and severity of AMS. We performed a cross-sectional study of travelers ascending through Pheriche, Nepal (4,240 m), from March 3 to May 14, 2006. AMS was assessed using the Lake Louise score. Optic nerve sheath diameter was measured by ultrasound. Ultrasound exams were performed and read by separate blinded observers. Two-hundred eighty seven subjects were enrolled. Ten of these underwent repeat examination. Mean optic nerve sheath diameter was 5.34 mm [95% confidence interval (CI) 5.18\u20135.51 mm] in the 69 subjects with AMS vs. 4.46 mm (95% CI 4.39\u20134.54 mm) in the 218 other subjects ( P &lt; 0.0001). There was also a positive association between optic nerve sheath diameter and total Lake Louise score ( P for trend &lt; 0.0001). In a multivariate logistic regression model of factors associated with AMS, optic nerve sheath diameter was strongly associated with AMS (odds ratio 6.3; 95% CI, 3.7\u201310.8; P &lt; 0.001). In 10 subjects with repeat examinations, change in Lake Louise score had a strong positive correlation with change in optic nerve sheath diameter ( R\n                    <jats:sup>2<\/jats:sup>\n                    = 0.84, P &lt; 0.001). Optic nerve sheath diameter, a proxy for intracranial pressure, is associated with the presence and severity of AMS.\n                  <\/jats:p>","DOI":"10.1152\/japplphysiol.01188.2007","type":"journal-article","created":{"date-parts":[[2008,12,31]],"date-time":"2008-12-31T20:34:20Z","timestamp":1230755660000},"page":"1207-1211","source":"Crossref","is-referenced-by-count":65,"title":["Optic nerve sheath diameter correlates with the presence and severity of acute mountain sickness: evidence for increased intracranial pressure"],"prefix":"10.1152","volume":"106","author":[{"given":"Peter J.","family":"Fagenholz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Gutman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice F.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicki E.","family":"Noble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Carlos A.","family":"Camargo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Stuart","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-8266(02)00036-8"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1089\/1527029041352108"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13591-X"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.2003.tb01352.x"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.2002.tb02166.x"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.126.5.644"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2004.00619.x"},{"key":"R9","doi-asserted-by":"crossref","unstructured":"Galetta S\n                      , Byrne SF, Smith JL.\n                      Echographic correlation of optic nerve sheath size and cerebrospinal fluid pressure.\n                      J Clin Neuroopthalmol\n                      9\n                      : 79\u201382, 1989.","DOI":"10.1001\/archneur.1989.00520370081024"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0797-6"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(83)90088-9"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200107123450206"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1997.87.1.0034"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1007\/BF01627611"},{"key":"R15","unstructured":"Hartig GS\n                      , Hackett PH.\n                      Cerebral spinal fluid pressure and cerebral blood velocity in acute mountain sickness. In:\n                      Hypoxia and Mountain Medicine\n                      , edited by Sutton JR, Coates G, Houston CS. Burlington, VT: Queen City, 1992, p. 260\u2013265."},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-118-8-199304150-00003"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600404"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.2007.00031.x"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1378\/chest.92.5.814"},{"key":"R20","unstructured":"Lake Louise Consensus Committee.\n                      The Lake Louise consensus on the definition and quantification of altitude illness. In:\n                      Hypoxia and Molecular Medicine\n                      , edited by Sutton J, Coates G, Houston C. Burlington, VT: Queen City, 1993."},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198912213212504"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)73195-2"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2000.7596"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.10.1109"},{"key":"R25","unstructured":"Roach RC\n                      , Hackett PH.\n                      Frontiers of hypoxia research: acute mountain sickness.\n                      J Exp Biol\n                      204\n                      : 3161\u20133170, 2001."},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2006.06.040"},{"key":"R27","unstructured":"Ward MP\n                      , West JB, Milledge JS.\n                      Scoring AMS symptoms. In:\n                      High Altitude Medicine and Physiology.\n                      London: Arnold, 2000, p. 372."},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1042\/cs0890201"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.01188.2007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T17:37:36Z","timestamp":1567964256000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/japplphysiol.01188.2007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["10.1152\/japplphysiol.01188.2007"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.01188.2007","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4]]}}}