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Seven healthy physically active nonsmoking men, aged 22.4 \u00b1 1.8 (mean \u00b1 SD) yr, maximum V\u0307o<jats:sub>2<\/jats:sub>(V\u0307o<jats:sub>2 max<\/jats:sub>) 50.4 \u00b1 4 ml\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7kg<jats:sup>\u22121<\/jats:sup>, performed two bouts of cycling, corresponding to 40 and 87% of V\u0307o<jats:sub>2 max<\/jats:sub>, lasting 6 min each, separated by a 20-min pause, once as a control study and a few days later at \u223c90 min after ingestion of 3 mmol\/kg body wt of NaHCO<jats:sub>3<\/jats:sub>. Blood samples for measurements of bicarbonate concentration and hydrogen ion concentration were taken from antecubital vein via catheter. Pulmonary V\u0307o<jats:sub>2<\/jats:sub>was measured continuously breath by breath. The values of \u03c4<jats:sub>1<\/jats:sub>were calculated by using six various approaches published in the literature. Preexercise level of bicarbonate concentration after ingestion of NaHCO<jats:sub>3<\/jats:sub>was significantly elevated ( P &lt; 0.01) compared with the control study (28.96 \u00b1 2.11 vs. 24.84 \u00b1 1.18 mmol\/l; P &lt; 0.01), and [H<jats:sup>+<\/jats:sup>] was significantly ( P &lt; 0.01) reduced (42.79 \u00b1 3.38 nmol\/l vs. 46.44 \u00b1 3.51 nmol\/l). This shift ( P &lt; 0.01) was also present during both bouts of exercise. During cycling at 40% of V\u0307o<jats:sub>2 max<\/jats:sub>, no significant effect of the preexercise alkalosis on the magnitude of \u03c4<jats:sub>1<\/jats:sub>was found. However, during cycling at 87% of V\u0307o<jats:sub>2 max<\/jats:sub>, the \u03c4<jats:sub>1<\/jats:sub>calculated by all six approaches was significantly ( P &lt; 0.05) reduced, compared with the control study. The \u03c4<jats:sub>1<\/jats:sub>calculated as in Borrani et al. (Borrani F, Candau R, Millet GY, Perrey S, Fuchsloscher J, and Rouillon JD. J Appl Physiol 90: 2212\u20132220, 2001) was reduced on average by 7.9 \u00b1 2.6 s, which was significantly different from zero with both the Student's t-test ( P = 0.011) and the Wilcoxon's signed-ranks test ( P = 0.014).<\/jats:p>","DOI":"10.1152\/japplphysiol.01194.2003","type":"journal-article","created":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T01:13:48Z","timestamp":1099271628000},"page":"895-904","source":"Crossref","is-referenced-by-count":26,"title":["Preexercise metabolic alkalosis induced via bicarbonate ingestion accelerates V\u0307<scp>o<\/scp><sub>2<\/sub>kinetics at the onset of a high-power-output exercise in humans"],"prefix":"10.1152","volume":"98","author":[{"given":"Jerzy A.","family":"Zoladz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zbigniew","family":"Szkutnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Duda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Majerczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Korzeniewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2002.282.1.R273"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.75.2.755"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.81.4.1642"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.90.6.2212"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1007\/s004210100514"},{"key":"R6","doi-asserted-by":"crossref","unstructured":"Chance Band Williams GR.The respiratory chain and oxidative phosphorylation.Adv Enzymol Relat Areas Mol Biol17: 65\u2013134, 1956.","DOI":"10.1002\/9780470122624.ch2"},{"key":"R7","unstructured":"Connett Rand Sahlin K.Control of glycolysis and glycogen metabolism. 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