{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:08:46Z","timestamp":1791212926035,"version":"4.1.0"},"reference-count":28,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:p> We tested the hypothesis that heliox breathing, by reducing lung dynamic hyperinflation (DH) and dyspnea (Dys) sensation, may significantly improve exercise endurance capacity in patients with chronic obstructive pulmonary disease [ n = 12, forced expiratory volume in 1 s = 1.15 (SD 0.32) liters]. Each subject underwent two cycle ergometer high-intensity constant work rate exercises to exhaustion, one on room air and one on heliox (79% He-21% O<jats:sub>2<\/jats:sub>). Minute ventilation (V\u0307e), carbon dioxide output, heart rate, inspiratory capacity (IC), Dys, and arterial partial pressure of CO<jats:sub>2<\/jats:sub> were measured. Exercise endurance time increased significantly with heliox [9.0 (SD 4.5) vs. 4.2 (SD 2.0) min; P &lt; 0.001]. This was associated with a significant reduction in lung DH at isotime (Iso), as reflected by the increase in IC [1.97 (SD 0.40) vs. 1.77 (SD 0.41) liters; P &lt; 0.001] and a decrease in Dys [6 (SD 1) vs. 8 (SD 1) score; P &lt; 0.001]. Heliox induced a state of relative hyperventilation, as reflected by the increase in V\u0307e [38.3 (SD 7.7) vs. 35.5 (SD 8.8) l\/min; P &lt; 0.01] and V\u0307e\/carbon dioxide output [36.3 (SD 6.0) vs. 33.9 (SD 5.6); P &lt; 0.01] at peak exercise and by the reduction in arterial partial pressure of CO<jats:sub>2<\/jats:sub> at Iso [44 (SD 6) vs. 48 (SD 6) Torr; P &lt; 0.05] and at peak exercise [46 (SD 6) vs. 48 (SD 6) Torr; P &lt; 0.05]. The reduction in Dys at Iso correlated significantly ( R = \u22120.75; P &lt; 0.01) with the increase in IC induced by heliox. The increment induced by heliox in exercise endurance time correlated significantly with resting increment in resting forced expiratory in 1 s ( R = 0.88; P &lt; 0.01), increase in IC at Iso ( R = 0.70; P &lt; 0.02), and reduction in Dys at Iso ( R = \u22120.71; P &lt; 0.01). In chronic obstructive pulmonary disease, heliox breathing improves high-intensity exercise endurance capacity by increasing maximal ventilatory capacity and by reducing lung DH and Dys. <\/jats:p>","DOI":"10.1152\/japplphysiol.01207.2003","type":"journal-article","created":{"date-parts":[[2004,7,2]],"date-time":"2004-07-02T20:48:41Z","timestamp":1088801321000},"page":"1637-1642","source":"Crossref","is-referenced-by-count":126,"title":["Effect of heliox on lung dynamic hyperinflation, dyspnea, and exercise endurance capacity in COPD patients"],"prefix":"10.1152","volume":"97","author":[{"given":"Paolo","family":"Palange","sequence":"first","affiliation":[{"name":"Dipartimento di Medicina Clinica, Servizio di Fisiopatologia Respiratoria, Universit\u00e0 \u201cLa Sapienza\u201d, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Valli","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Clinica, Servizio di Fisiopatologia Respiratoria, Universit\u00e0 \u201cLa Sapienza\u201d, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Onorati","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Clinica, Servizio di Fisiopatologia Respiratoria, Universit\u00e0 \u201cLa Sapienza\u201d, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Antonucci","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Clinica, Servizio di Fisiopatologia Respiratoria, Universit\u00e0 \u201cLa Sapienza\u201d, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Paoletti","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Clinica, Servizio di Fisiopatologia Respiratoria, Universit\u00e0 \u201cLa Sapienza\u201d, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Rosato","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Clinica, Servizio di Fisiopatologia Respiratoria, Universit\u00e0 \u201cLa Sapienza\u201d, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felice","family":"Manfredi","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Clinica, Servizio di Fisiopatologia Respiratoria, Universit\u00e0 \u201cLa Sapienza\u201d, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Serra","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Clinica, Servizio di Fisiopatologia Respiratoria, Universit\u00e0 \u201cLa Sapienza\u201d, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","unstructured":"Adams L and Guz A. Dyspnea on exercise. In: Exercise, Pulmonary Physiology and Pathophysiology: Lung Biology in Health and Disease, edited by Whipp BJ and Wasserman K. New York: Dekker, 1991, vol. 52, p. 449\u2013487."},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1985.58.4.1051"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.82.3.746"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(97)84026-1"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.5.9908025"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1973.34.1.128"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.313.7048.41"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1159\/000194298"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1983.54.2.387"},{"key":"R10","unstructured":"Fairshter RD. Density-dependence of maximal expiratory flow. 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No. 2701)"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.2.9907122"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1007\/BF00585169"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.4.2007026"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.5.9804004"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/148.5.1351"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1042\/cs0390675"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.3.9803049"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/137.1.206"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(82)90116-5"},{"key":"R28","unstructured":"Whipp BJ, Wagner PD, and Agusti A. Factors determining the response to exercise in healthy subjects. In: Clinical Exercise Testing, edited by Roca J and Whipp BJ. 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