{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:59:48Z","timestamp":1792569588390,"version":"4.5.0"},"reference-count":55,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/501100021692","name":"LabEx PRIMES","doi-asserted-by":"publisher","award":["ANR-11-LABX-0063"],"award-info":[{"award-number":["ANR-11-LABX-0063"]}],"id":[{"id":"10.13039\/501100021692","id-type":"DOI","asserted-by":"publisher"}]},{"name":"France Life Imaging","award":["grant ANR-11-INBS-0006"],"award-info":[{"award-number":["grant ANR-11-INBS-0006"]}]},{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"crossref","award":["ANR-11-IDEX-0007"],"award-info":[{"award-number":["ANR-11-IDEX-0007"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["STROBE-UA07"],"award-info":[{"award-number":["STROBE-UA07"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006451","name":"Hospices Civils de Lyon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006451","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030971","name":"Centre Hospitalier Universitaire Grenoble Alpes","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100030971","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:p>This study presents a computational model for simulating ventilatory response in mechanically ventilated patients with acute respiratory distress syndrome and introduces a novel method to estimate patient-specific lung mechanical properties from a dual-volume computed tomography (CT) protocol. The key purpose of the in silico model proposed in this paper is to provide clinicians with a complementary modality that supports decision-making surrounding mechanical ventilation.<\/jats:p>","DOI":"10.1152\/japplphysiol.01215.2025","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T14:10:46Z","timestamp":1774361446000},"page":"1139-1151","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Patient-specific lung simulation incorporating regional elastance and recruitment to guide mechanical ventilation in acute respiratory distress syndrome"],"prefix":"10.1152","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7973-3519","authenticated-orcid":false,"given":"Ruby","family":"Dunphy","sequence":"first","affiliation":[{"name":"Eindhoven University of Technology","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4496-3998","authenticated-orcid":false,"given":"Sjeng","family":"Quicken","sequence":"additional","affiliation":[{"name":"Eindhoven University of Technology","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0358-7849","authenticated-orcid":false,"given":"Jur Van","family":"Kimmenade","sequence":"additional","affiliation":[{"name":"Eindhoven University of Technology","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julianna","family":"Mangold","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes, STROBE Inserm UA07","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1923-9356","authenticated-orcid":false,"given":"Mehdi","family":"Shekarnabi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes, STROBE Inserm UA07","place":["France"]},{"name":"Universit\u00e9 Claude Bernard Lyon, INSA-Lyon, CNRS, Inserm, CREATIS UMR 5220","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8899-7955","authenticated-orcid":false,"given":"Vicente","family":"Estopier Castillo","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes, STROBE Inserm UA07","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1709-5766","authenticated-orcid":false,"given":"Maciej","family":"Orkisz","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Claude Bernard Lyon, INSA-Lyon, CNRS, Inserm, CREATIS UMR 5220","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"De Bie Dekker","sequence":"additional","affiliation":[{"name":"Catharina Hospital Eindhoven","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6812-9433","authenticated-orcid":false,"given":"Igor","family":"Paulussen","sequence":"additional","affiliation":[{"name":"Catharina Hospital Eindhoven","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1503-3035","authenticated-orcid":false,"given":"Jean-Christophe","family":"Richard","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Claude Bernard Lyon, INSA-Lyon, CNRS, Inserm, CREATIS UMR 5220","place":["France"]},{"name":"Hospices Civils de Lyon, Croix Rousse Hospital","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0779-4785","authenticated-orcid":false,"given":"Wouter","family":"Huberts","sequence":"additional","affiliation":[{"name":"Eindhoven University of Technology","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8565-0293","authenticated-orcid":false,"given":"Sam","family":"Bayat","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes, STROBE Inserm UA07","place":["France"]},{"name":"Grenoble University Hospital","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.21907"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-16-8371-8_2"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12134176"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000431"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70074"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-005-2627-z"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1186\/s40635-017-0121-x"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-77300-x"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-023-07296-1"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1115\/1.4054386"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0186-2022"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3390\/tomography9050150"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00313.2025"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.984286"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2022.0062"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-023-04549-9"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.3745"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00741.2024"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-025-03232-7"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2013.2246577"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.5669"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1109\/ISBI53787.2023.10230395"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-59006-2_5"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011444826908"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00520.2004"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1148\/ryai.230024"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1080\/21681163.2015.1023358"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.2577"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(70)90094-0"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00795.2004"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00236.2016"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2016.2572678"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1136\/thx.41.8.620"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-87553-3_11"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200308-1107OC"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.829534"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00289-2020"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1115\/1.429644"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.84.1.389"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1097\/CCE.0000000000000299"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.12061"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/156094"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052052"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000770"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03578-6"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000916"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.congress-2020.1933"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00123.2017"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00112.2015"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90806.2008"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002234"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/usad059"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-021-01502-z"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00941"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1115\/1.4069032"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.01215.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:59:06Z","timestamp":1780581546000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/japplphysiol.01215.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,1]]},"references-count":55,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,1]]}},"alternative-id":["10.1152\/japplphysiol.01215.2025"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.01215.2025","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,1]]},"assertion":[{"value":"2025-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-29","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}