{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T21:09:17Z","timestamp":1769202557836,"version":"3.49.0"},"reference-count":28,"publisher":"American Physiological Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2014,4,1]]},"abstract":"<jats:p>Acetazolamide (ACZ) prevents hypoxic pulmonary vasoconstriction (HPV) in isolated lungs, animals, and humans, but not by carbonic anhydrase (CA) inhibition. We studied administration routes in, and certain structural aspects of, ACZ critical to HPV inhibition. Analogs of ACZ during acute hypoxia were tested in unanesthetized dogs. Dogs breathed normoxic gas for 1 h (inspired O<jats:sub>2<\/jats:sub>fraction = 0.21), followed by 10% O<jats:sub>2<\/jats:sub>for 2 h (hypoxia) in these protocols: 1) controls; 2) ACZ intravenously (2 mg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7h<jats:sup>\u22121<\/jats:sup>); 3) ACZ orally (5 mg\/kg, 12 and 1 h before the experiment); 4) inhaled ACZ (750 mg); 5) methazolamide (MTZ) intravenously (3 mg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7h<jats:sup>\u22121<\/jats:sup>); and 6) N-methyl-acetazolamide (NMA) intravenously (10 mg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7h<jats:sup>\u22121<\/jats:sup>). In controls, mean pulmonary arterial pressure (MPAP) increased 7 mmHg, and pulmonary vascular resistance (PVR) 224 dyn\u00b7s\u00b7cm<jats:sup>\u22125<\/jats:sup>with hypoxia ( P &lt; 0.05). With intravenous and inhaled ACZ, MPAP and PVR did not change during hypoxia. With oral ACZ, HPV was only slightly suppressed; MPAP increased 5 mmHg and PVR by 178 dyn\u00b7s\u00b7cm<jats:sup>\u22125<\/jats:sup>during hypoxia. With MTZ and NMA, the MPAP rise (4 \u00b1 2 mmHg) was reduced, and PVR did not increase during hypoxia compared with normoxia (MTZ intravenous: 81 \u00b1 77 and 68 \u00b1 82 dyn\u00b7s\u00b7cm<jats:sup>\u22125<\/jats:sup>with NMA intravenous). Inhaled ACZ prevents HPV, but not without causing systemic CA inhibition. NMA, a compound lacking CA inhibiting effects by methylation at the sulfonamide moiety, and MTZ, a CA-inhibiting analog methylated at the thiadiazole ring, are only slightly less effective than ACZ in reducing HPV.<\/jats:p>","DOI":"10.1152\/japplphysiol.01235.2013","type":"journal-article","created":{"date-parts":[[2014,1,31]],"date-time":"2014-01-31T05:08:06Z","timestamp":1391144886000},"page":"715-723","source":"Crossref","is-referenced-by-count":24,"title":["Pulmonary vasodilation by acetazolamide during hypoxia: impact of methyl-group substitutions and administration route in conscious, spontaneously breathing dogs"],"prefix":"10.1152","volume":"116","author":[{"given":"Philipp A.","family":"Pickerodt","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, Campus Charit\u00e9 Mitte and Campus Virchow-Klinikum, Charit\u00e9-University Medicine, Berlin, Germany;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland C.","family":"Francis","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, Campus Charit\u00e9 Mitte and Campus Virchow-Klinikum, Charit\u00e9-University Medicine, Berlin, Germany;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"H\u00f6hne","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, University of Leipzig, Leipzig, Germany;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friederike","family":"Neubert","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, Campus Charit\u00e9 Mitte and Campus Virchow-Klinikum, Charit\u00e9-University Medicine, Berlin, Germany;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stella","family":"Telalbasic","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, Campus Charit\u00e9 Mitte and Campus Virchow-Klinikum, Charit\u00e9-University Medicine, Berlin, Germany;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willehad","family":"Boemke","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, Campus Charit\u00e9 Mitte and Campus Virchow-Klinikum, Charit\u00e9-University Medicine, Berlin, Germany;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik R.","family":"Swenson","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, University of Washington, Seattle, Washington; 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