{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:54:52Z","timestamp":1773420892007,"version":"3.50.1"},"reference-count":38,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2014,3,1]]},"abstract":"<jats:p> The study aimed to investigate whether the extent of activities of daily living (ADL) of patients after myocardial infarction affect numbers of circulating CD34<jats:sup>+<\/jats:sup>\/KDR<jats:sup>+<\/jats:sup> and CD45<jats:sup>+<\/jats:sup>\/CD34<jats:sup>+<\/jats:sup> cells, which are supposed to protect structural and functional endothelial integrity. In a cross-sectional study, 34 male coronary artery disease patients with a history of myocardial infarction were assessed for times spent per week for specific physical ADL, including basic activities (instrumental ADL), leisure time activities, and sport activities, using a validated questionnaire. Individual specific activity times were multiplied with respective specific metabolic equivalent scores to obtain levels of specific activities. Numbers of circulating CD34<jats:sup>+<\/jats:sup>\/KDR<jats:sup>+<\/jats:sup> and CD45<jats:sup>+<\/jats:sup>\/CD34<jats:sup>+<\/jats:sup> cells were analyzed by flow cytometry. Furthermore, the colony-forming capacity of CD34<jats:sup>+<\/jats:sup> cells and the level of granulocyte colony-stimulating factor (G-CSF) in serum were measured. Analysis revealed that the extent of total activities and basic activities, as well as total activity time, were positively correlated with numbers of circulating CD34<jats:sup>+<\/jats:sup>\/KDR<jats:sup>+<\/jats:sup> cells ( r = 0.60, 0.56, and 0.55, P &lt; 0.05). Higher levels of total activity were also associated with increased colony-forming capacity of CD34<jats:sup>+<\/jats:sup> cells ( r = 0.54, P &lt; 0.05) and with higher systemic levels of G-CSF ( r = 0.44, P &lt; 0.05). These findings indicate that even ADL-related activities of coronary artery disease patients after myocardial infarction exert stimulating effects on CD34<jats:sup>+<\/jats:sup>\/KDR<jats:sup>+<\/jats:sup> cell mobilization, potentially mediated by increased G-CSF levels. This, in turn, potentially contributes to the beneficial effects of exercise on the diseased cardiovascular system. <\/jats:p>","DOI":"10.1152\/japplphysiol.01254.2013","type":"journal-article","created":{"date-parts":[[2014,1,10]],"date-time":"2014-01-10T05:43:07Z","timestamp":1389332587000},"page":"532-537","source":"Crossref","is-referenced-by-count":10,"title":["Activity of daily living is associated with circulating CD34<sup>+<\/sup>\/KDR<sup>+<\/sup> cells and granulocyte colony-stimulating factor levels in patients after myocardial infarction"],"prefix":"10.1152","volume":"116","author":[{"given":"Karsten","family":"Kr\u00fcger","sequence":"first","affiliation":[{"name":"Department of Sports Medicine, Institute of Sports Sciences, Justus-Liebig-University, Giessen, Germany; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Klocke","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, University of M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Kloster","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Institute of Sports Sciences, Justus-Liebig-University, Giessen, Germany; 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