{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T14:18:22Z","timestamp":1770733102812,"version":"3.49.0"},"reference-count":38,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:p> This study was conducted to investigate effects of an acute sodium load on resting plasma volume (PV) and renal mechanisms across the menstrual cycle of endurance-trained women with natural (NAT) or oral contraceptive pill (OCP) controlled cycles. Twelve women were assigned to one of two groups, according to their usage status: 1) OCP [ n = 6, 29 yr (SD 6), 59.4 kg (SD 3.2)], or 2) NAT [ n = 6, 24 yr (SD 5), 61.3 kg (SD 3.6)]. The sodium load was administered as a concentrated sodium chloride\/citrate beverage (164 mmol Na<jats:sup>+<\/jats:sup>\/l, 253 mosmol\/kgH<jats:sub>2<\/jats:sub>O, 10 ml\/kg body mass) during the last high-hormone week of the OCP cycle (OCP<jats:sub>high<\/jats:sub>) or late luteal phase of the NAT cycle (NAT<jats:sub>high<\/jats:sub>) and during the low-hormone sugar pill week of OCP (OCP<jats:sub>low<\/jats:sub>) or early follicular phase of the NAT cycle (NAT<jats:sub>low<\/jats:sub>). The beverage (\u223c628 ml) was ingested in seven portions across 60 min. Over the next 4 h, PV expanded more in the low-hormone phase for both groups (time-averaged change): OCP<jats:sub>low<\/jats:sub> 6.1% (SD 1.1) and NAT<jats:sub>low<\/jats:sub> 5.4% (SD 1.2) vs. OCP<jats:sub>high<\/jats:sub> 3.9% (SD 0.9) and NAT<jats:sub>high<\/jats:sub> 3.5% (SD 0.8) ( P = 0.02). The arginine vasopressin increased less in the low-hormone phase [1.63 (SD 0.2) and 1.30 pg\/ml (SD 0.2) vs. 1.82 (SD 0.3) and 1.57 pg\/ml (SD 0.5), P = 0.0001], as did plasma aldosterone concentration (\u223c64% lower, P = 0.0001). Thus PV increased more and renal hormone sensitivity was decreased in the low-hormone menstrual phase following sodium\/fluid ingestion, irrespective of OCP usage. <\/jats:p>","DOI":"10.1152\/japplphysiol.01331.2007","type":"journal-article","created":{"date-parts":[[2008,4,25]],"date-time":"2008-04-25T01:09:35Z","timestamp":1209085775000},"page":"121-127","source":"Crossref","is-referenced-by-count":24,"title":["Endogenous and exogenous female sex hormones and renal electrolyte handling: effects of an acute sodium load on plasma volume at rest"],"prefix":"10.1152","volume":"105","author":[{"given":"Stacy T.","family":"Sims","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy J.","family":"Rehrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie L.","family":"Bell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James D.","family":"Cotter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1992.tb14507.x"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1991.70.5.1917"},{"key":"R3","unstructured":"Bungo MW, Charles JB, Johnson PC. Cardiovascular deconditioning during spaceflight and the use of saline as a countermeasure to orthostatic intolerance. Aviat Space Environ Med 56: 985\u2013990, 1985."},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00224.2002"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(02)00344-X"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1974.37.2.247"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1916.00080130010002"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(96)00136-9"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2006.10.011"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1971.30.6.847"},{"key":"R11","unstructured":"Greenleaf JE, Jackson CG, Geelen G, Keil LC, Hinghofer-Szalkay H, Whittam JH. Plasma volume expansion with oral fluids in hypohydrated men at rest and during exercise. Aviat Space Environ Med 69: 837\u2013844, 1998."},{"key":"R12","unstructured":"Greenleaf JE, Looft-Wilson R, Wisherd JL, McKenzie MA, Jensen CD, Whittam JH. Pre-exercise hypervolemia and cycle ergometer endurance in men. Biol Sport 14: 103\u2013114, 1997."},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1985.59.6.1690"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2001.280.3.R807"},{"key":"R15","unstructured":"Karim SMM. Prostaglandins and human reproduction: physiological roles and clinical uses of prostaglandins in relation to human reproduction. In: The Prostaglandins, edited by Karim SMM. Oxford, UK: MTP, 1972 p. 84\u201388."},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70292-3"},{"key":"R17","doi-asserted-by":"crossref","unstructured":"Kuhl H. Comparative pharmacology of newer progestogens. Drugs 51: 188\u2013215, 2001.","DOI":"10.2165\/00003495-199651020-00002"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00321.2002"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.8.862"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1996.270.4.E601"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1016\/0039-128X(96)00007-4"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(87)90364-4"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00239.x"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000106181.52102.99"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01203.2006"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000241639.97972.4a"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(96)00137-0"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1985.tb01062.x"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00192.2002"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2001.281.4.R1319"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.3.1016"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.4.1893"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01032.2003"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00031.2005"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1154"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(92)90160-U"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.3109\/00016349309068030"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1988.254.4.R641"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.01331.2007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T22:22:53Z","timestamp":1567981373000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/japplphysiol.01331.2007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1152\/japplphysiol.01331.2007"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.01331.2007","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7]]}}}