{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T18:50:59Z","timestamp":1776451859137,"version":"3.51.2"},"reference-count":37,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:p>Acute \u03b2-blockade with metoprolol has been associated with increased mortality by undefined mechanisms. Since metoprolol is a relatively high affinity blocker of \u03b2<jats:sub>2<\/jats:sub>-adrenoreceptors, we hypothesized that some of the increased mortality associated with its use may be due to its abrogation of \u03b2<jats:sub>2<\/jats:sub>-adrenoreceptor-mediated vasodilation of microvessels in different vascular beds. Cardiac output (CO; pressure volume loops), mean arterial pressure (MAP), relative cerebral blood flow (rCBF; laser Doppler), and microvascular brain tissue Po<jats:sub>2<\/jats:sub>(G2 oxyphor) were measured in anesthetized mice before and after acute treatment with metoprolol (3 mg\/kg iv). The vasodilatory dose responses to \u03b2-adrenergic agonists (isoproterenol and clenbuterol), and the myogenic response, were assessed in isolated mesenteric resistance arteries (MRAs; \u223c200-\u03bcm diameter) and posterior cerebral arteries (PCAs \u223c150-\u03bcm diameter). Data are presented as means \u00b1 SE with statistical significance applied at P &lt; 0.05. Metoprolol treatment did not effect MAP but reduced heart rate and stroke volume, CO, rCBF, and brain microvascular Po<jats:sub>2<\/jats:sub>, while concurrently increasing systemic vascular resistance ( P &lt; 0.05 for all). In isolated MRAs, metoprolol did not affect basal artery tone or the myogenic response, but it did cause a dose-dependent impairment of isoproterenol- and clenbuterol-induced vasodilation. In isolated PCAs, metoprolol (50 \u03bcM) impaired maximal vasodilation in response to isoproterenol. These data support the hypothesis that acute administration of metoprolol can reduce tissue oxygen delivery by impairing the vasodilatory response to \u03b2<jats:sub>2<\/jats:sub>-adrenergic agonists. This mechanism may contribute to the observed increase in mortality associated with acute administration of metoprolol in perioperative patients.<\/jats:p>","DOI":"10.1152\/japplphysiol.01340.2010","type":"journal-article","created":{"date-parts":[[2011,7,29]],"date-time":"2011-07-29T03:14:35Z","timestamp":1311909275000},"page":"1125-1133","source":"Crossref","is-referenced-by-count":27,"title":["Metoprolol impairs resistance artery function in mice"],"prefix":"10.1152","volume":"111","author":[{"given":"Mostafa H.","family":"El Beheiry","sequence":"first","affiliation":[{"name":"Department of Anesthesia, St. Michael's Hospital, Keenan Research Centre of the Li Ka Shing Knowledge Institute, University of Toronto;"},{"name":"Department of Physiology, University of Toronto;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott P.","family":"Heximer","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Toronto;"},{"name":"Heart &amp; Stroke\/Richard Lewar Centre of Excellence, University of Toronto;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Voigtlaender-Bolz","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, St. Michael's Hospital, Keenan Research Centre of the Li Ka Shing Knowledge Institute, University of Toronto;"},{"name":"Toronto Centre for Microvascular Medicine, University of Toronto;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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