{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T07:55:54Z","timestamp":1681372554536},"reference-count":27,"publisher":"American Physiological Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2013,4,1]]},"abstract":"<jats:p> Pleural effusion, a complicating feature of many diseases of the lung and pleura, adversely affects the pressure-generating capacity of the diaphragm in supine dogs. The objective of the present study was to assess the impact of body position on this effect and to evaluate the adaptation to effusion of the inspiratory muscle pump during breathing. Two experiments were performed. In the first, progressively increasing effusion was induced in anesthetized animals, and the changes in pleural (\u0394Ppl) and abdominal (\u0394Pab) pressure were measured during isolated phrenic nerve stimulation while the animals were placed in both the supine and the 45\u00b0 head-up posture. In the second experiment, graded pleural effusion was also performed, and \u0394Ppl, \u0394Pab, and the electromyogram of the parasternal intercostal muscles were measured while the vagotomized animals were breathing spontaneously in the same two postures. The data showed that with effusion 1) \u0394Ppl during phrenic nerve stimulation was substantially lower with the animals in the head-up than in the supine posture; 2) this postural effect was primarily the result of the decrease in muscle length in the head-up posture; 3) during spontaneous breathing, however, parasternal intercostal inspiratory activity increased and \u0394Ppl remained unaltered while \u0394Pab decreased; and 4) the decrease in \u0394Pab and in the \u0394Pab\/\u0394Ppl ratio was much larger in the head-up than in the supine posture. It is concluded that in the presence of pleural effusion, the pressure contribution of the inspiratory intercostal muscles during breathing increases and compensates for the shortening of the diaphragm, particularly in the upright posture. <\/jats:p>","DOI":"10.1152\/japplphysiol.01392.2012","type":"journal-article","created":{"date-parts":[[2013,2,8]],"date-time":"2013-02-08T08:08:42Z","timestamp":1360310922000},"page":"941-947","source":"Crossref","is-referenced-by-count":1,"title":["Function of the canine inspiratory muscle pump in pleural effusion: influence of body position"],"prefix":"10.1152","volume":"114","author":[{"given":"Dimitri","family":"Leduc","sequence":"first","affiliation":[{"name":"Laboratory of Cardiorespiratory Physiology, Brussels School of Medicine, Brussels, and Chest Service, Erasme University Hospital, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"De Troyer","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiorespiratory Physiology, Brussels School of Medicine, Brussels, and Chest Service, Erasme University Hospital, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","first-page":"788","volume":"126","author":"Baydur A","year":"1982","journal-title":"Am Rev Respir Dis"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.66.4.1699"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1378\/chest.74.5.540"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(80)90053-5"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.76.5.1993"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018657"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1997.445bh.x"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00446.2012"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00753.2009"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.79.1.55"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.91472.2008"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)91072-0"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1988.64.3.1060"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1988.65.1.72"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1983.127.4.431"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.60.4.1420"},{"key":"B17","first-page":"159","volume":"70","author":"Gilmartin JJ","year":"1987","journal-title":"Respir Physiol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1958.13.2.165"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1990.69.6.2050"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1985.58.5.1602"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1985.59.5.1458"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1978.44.2.200"},{"key":"B23","first-page":"543","volume":"111","author":"Neff TA","year":"1975","journal-title":"Am Rev Respir Dis"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1984.57.2.576"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1969.sp008868"},{"key":"B26","first-page":"195","volume":"76","author":"Simmons DH","year":"1957","journal-title":"Am Rev Tuberc Pulm Dis"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1997.673bg.x"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.01392.2012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T22:59:46Z","timestamp":1567983586000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/japplphysiol.01392.2012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,1]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,4,1]]}},"alternative-id":["10.1152\/japplphysiol.01392.2012"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.01392.2012","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,1]]}}}