{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:22:54Z","timestamp":1790940174842,"version":"4.1.0"},"reference-count":32,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:p>Astronauts experience spine deconditioning during exposure to microgravity due to the lack of axial loads on the spine. Treadmill exercise in a lower body negative pressure (LBNP) chamber provides axial loads on the lumbar spine. We hypothesize that daily supine LBNP exercise helps counteract lumbar spine deconditioning during 28 days of microgravity simulated by bed rest. Twelve sets of healthy, identical twins underwent 6\u00b0 head-down-tilt bed rest for 28 days. One subject from each set of twins was randomly assigned to the exercise (Ex) group, whereas their sibling served as a nonexercise control (Con). The Ex group exercised in supine posture within a LBNP chamber for 45 min\/day, 6 days\/wk. All subjects underwent magnetic resonance imaging of their lumbar spine before and at the end of bed rest. Lumbar spinal length increased 3.7 \u00b1 0.5 mm in the Con group over 28-day bed rest, whereas, in the Ex group, lumbar spinal length increased significantly less (2.3 \u00b1 0.4 mm, P = 0.01). All lumbar intervertebral disk heights (L<jats:sub>5<\/jats:sub>\u2013S<jats:sub>1<\/jats:sub>, L<jats:sub>4\u20135<\/jats:sub>, L<jats:sub>3\u20134<\/jats:sub>, L<jats:sub>2\u20133<\/jats:sub>, and L<jats:sub>1\u20132<\/jats:sub>) in the Con group increased significantly over the 28-day bed rest ( P &lt; 0.05). In the Ex group, there were no significant increases in L<jats:sub>5<\/jats:sub>\u2013S<jats:sub>1<\/jats:sub>and L<jats:sub>4\u20135<\/jats:sub>disk heights. Lumbar lordosis decreased significantly by 3.3 \u00b1 1.2\u00b0 during bed rest in the Con group ( P = 0.02), but it did not decrease significantly in the Ex group. Our results suggest that supine LBNP treadmill exercise partially counteracts lumbar spine lengthening and deconditioning associated with simulated microgravity.<\/jats:p>","DOI":"10.1152\/japplphysiol.01400.2004","type":"journal-article","created":{"date-parts":[[2005,3,10]],"date-time":"2005-03-10T22:01:43Z","timestamp":1110492103000},"page":"39-44","source":"Crossref","is-referenced-by-count":82,"title":["Exercise within lower body negative pressure partially counteracts lumbar spine deconditioning associated with 28-day bed rest"],"prefix":"10.1152","volume":"99","author":[{"given":"Peihong","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon R.","family":"Macias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald E.","family":"Watenpaugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan R.","family":"Hargens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-198309000-00013"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-197901000-00009"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.89.2.649"},{"key":"R4","unstructured":"Brown JW.Crew height measurements. 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