{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T03:38:21Z","timestamp":1773459501326,"version":"3.50.1"},"reference-count":52,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p>Hypoxic stimulation of the carotid body receptors (CBR) results in a rapid hyperglycemia with an increase in brain glucose retention. Previous work indicates that neurohypophysectomy inhibits this hyperglycemic response. Here, we show that systemic arginine vasopressin (AVP) induced a transient, but significant, increase in blood glucose levels and increased brain glucose retention, a response similar to that observed after CBR stimulation. Comparable results were obtained after intracerebral infusion of AVP. Systemic AVP-induced changes were maintained in hypophysectomized rats but were not observed after adrenalectomy. Glycemic changes after CBR stimulation were inhibited by pharmacological blockage of AVP V1a receptors with a V1a-selective receptor antagonist ([\u03b2-Mercapto-\u03b2,\u03b2-cyclopentamethylenepropionyl<jats:sup>1<\/jats:sup>,O-me-Tyr<jats:sup>2<\/jats:sup>, Arg<jats:sup>8<\/jats:sup>]-vasopressin). Importantly, local application of micro-doses of this antagonist to the liver was sufficient to abolish the hyperglycemic response after CBR stimulation. These results suggest that AVP is a mediator of the hyperglycemic reflex and cerebral glucose retention following CBR stimulation. We propose that hepatic activation of AVP V1a receptors is essential for this hyperglycemic response.<\/jats:p>","DOI":"10.1152\/japplphysiol.01414.2005","type":"journal-article","created":{"date-parts":[[2006,2,24]],"date-time":"2006-02-24T01:39:36Z","timestamp":1140745176000},"page":"1902-1909","source":"Crossref","is-referenced-by-count":18,"title":["Arginine-vasopressin mediates central and peripheral glucose regulation in response to carotid body receptor stimulation with Na-cyanide"],"prefix":"10.1152","volume":"100","author":[{"given":"Sergio","family":"Montero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Her\u00f3n","family":"Mendoza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Valles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f3nica","family":"Lemus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram\u00f3n","family":"Alvarez-Buylla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena R.","family":"de Alvarez-Buylla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(88)90093-X"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1997.272.1.R392"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2003.09.030"},{"key":"R4","unstructured":"Alvarez-Buylla R, Quintanar-Stephano A, Quintanar-Stephano JL, and Alvarez-Buylla de ER.Removal of the unfragmented pituitary gland (hypophysectomy) in the rat.Bol Estud Med Biol39: 33\u201338, 1991."},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)91585-7"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.2337\/diab.35.7.826"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.3.663"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1984.247.1.E41"},{"key":"R9","unstructured":"Bures J, Buresova O, and Huston JP.Techniques and Basic Experiments for the Study of Brain and Behavior. New York: Elsevier, 1983."},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1007\/BF01188499"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1159\/000126185"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1159\/000122702"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1042\/bj3330253"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.7.2863"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1999.277.2.R403"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1021\/jm00248a028"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1998.274.6.G1109"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.10.2542"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1984.57.4.931"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1988.tb31809.x"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-4871-3_41"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(91)90011-Q"},{"key":"R23","unstructured":"Houssay BA.The hypophysis. In:Human Physiology, edited by Houssay BA, Lewis JT, Or\u00edas O, Hug VG, and Leloir LF. New York: McGraw-Hill, 1951, p. 539."},{"key":"R24","unstructured":"Hudson LC, Hughes CS, Bold-Fletcher NO, and Vaden SL.Cerebrospinal fluid collection in rats: modification of a previous technique.Lab Anim Sci44: 358\u2013361, 1994."},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1210\/endo.143.1.8587"},{"key":"R26","unstructured":"Institute of Laboratory Animal Resources, Comission on Life Sciences, National Research Council.Guide for the Care and Use of Laboratory Animals. Washington, DC: Natl. Acad. Press, 1997."},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.13.6.935"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1977.tb05988.x"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(79)90371-4"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.9.1434"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00370.2001"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1992.263.2.R310"},{"key":"R33","unstructured":"Manning Mand Sawyer WH.Potent and specific vasopressin antagonist.Kidney Int Suppl26: S34\u2013S37, 1988."},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-9280-2_12"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00201.2001"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)82718-8"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.26.4.665"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1016\/0168-0102(95)00965-V"},{"key":"R39","doi-asserted-by":"crossref","unstructured":"Nishino T, Kodaira T, Shin S, Imagawa K, Shima K, Kumahara Y, Yanaihara C, and Yanaihara N.Glucagon radioimmunoassay with use of antiserum to glucagon C-terminal fragment.Clin Chem27: 1690\u20131697, 1981.","DOI":"10.1093\/clinchem\/27.10.1690"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1210\/endo.135.4.7925112"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1038\/nn812"},{"key":"R42","unstructured":"Pardal Rand L\u00f3pez-Barneo J.Combined oxygen and glucose sensing in the carotid body.Undersea Hyperb Med31: 113\u2013121, 2004."},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.88.6.2287"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)91125-3"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.1042\/bj2120231"},{"key":"R46","doi-asserted-by":"crossref","unstructured":"Share Land Levy MN.Effect of carotid chemoreceptor stimulation on plasma antidiuretic hormone titer.Am J Physiol210: 157\u2013161, 1966.","DOI":"10.1152\/ajplegacy.1966.210.1.157"},{"key":"R47","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2003.09.013"},{"key":"R48","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1988.89"},{"key":"R49","doi-asserted-by":"crossref","unstructured":"Uyama N, Geerts A, and Reynaert H.Neural connections between the hypothalamus and the liver.Anat Rec280: 808\u2013820, 2004.","DOI":"10.1002\/ar.a.20086"},{"key":"R50","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.61.2.522"},{"key":"R51","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)02404-0"},{"key":"R52","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1999.277.1.E56"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.01414.2005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T22:03:06Z","timestamp":1586728986000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/japplphysiol.01414.2005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":52,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1152\/japplphysiol.01414.2005"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.01414.2005","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6]]}}}