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In [\u2212]HSP72 or ICR, the values for mean arterial pressure, the striatal blood flow, and the striatal Po<jats:sub>2<\/jats:sub>after the onset of heatstroke were significantly lower than those in preheat controls. The core and brain temperatures, the extracellular concentrations of ischemic and injury markers in the striatum, and the striatal neuronal damage scores were significantly greater than those in the preheat controls. In [\u2212]HSP72 or ICR, the body temperatures, cell ischemia content, and injury marker in the striatum were significantly higher, and the mean arterial pressure, striatal blood flow, and striatal Po<jats:sub>2<\/jats:sub>concentration were significantly lower during heatstroke than in [+]HSP72. Accordingly, the latency and the survival times for [+]HSP72 significantly exceeded those of [\u2212]HSP72 or ICR. 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