{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:17:50Z","timestamp":1791346670321,"version":"4.3.1"},"reference-count":70,"publisher":"American Physiological Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2012,5,1]]},"abstract":"<jats:p>The aim of this study was to analyze the effects of exercise training on oxidative stress in sickle cell trait carriers. Plasma levels of oxidative stress [advanced oxidation protein products (AOPP), protein carbonyl, malondialdehyde (MDA), and nitrotyrosine], antioxidant markers [catalase, glutathione peroxidase (GPX), and superoxide dismutase (SOD)], and nitrite and nitrate (NOx) were assessed at baseline, immediately following a maximal exercise test (T<jats:sub>ex<\/jats:sub>), and during recovery (T<jats:sub>1h<\/jats:sub>, T<jats:sub>2h<\/jats:sub>, T<jats:sub>24h<\/jats:sub>) in trained (T: 8 h\/wk minimum) and untrained (U: no regular physical activity) sickle cell trait (SCT) carriers or control (CON) subjects (T-SCT, n = 10; U-SCT, n = 8; T-CON, n = 11; and U-CON, n = 11; age: 23.5 \u00b1 2.2 yr). The trained subjects had higher SOD activities (7.6 \u00b1 5.4 vs. 5.2 \u00b1 2.1 U\/ml, P = 0.016) and lower levels of AOPP (142 \u00b1 102 vs. 177 \u00b1 102 \u03bcM, P = 0.028) and protein carbonyl (82.1 \u00b1 26.0 vs. 107.3 \u00b1 30.6 nm\/ml, P = 0.010) than the untrained subjects in response to exercise. In response to exercise, U-SCT had a higher level of AOPP (224 \u00b1 130 vs. 174 \u00b1 121 \u03bcM, P = 0.012), nitrotyrosine (127 \u00b1 29.1 vs.70.6 \u00b1 46.6 nM, P = 0.003), and protein carbonyl (114 \u00b1 34.0 vs. 86.9 \u00b1 26.8 nm\/ml, P = 0.006) compared with T-SCT. T-SCT had a higher SOD activity (8.50 \u00b1 7.2 vs. 4.30 \u00b1 2.5 U\/ml, P = 0.002) and NOx (28.8 \u00b1 11.4 vs. 14.6 \u00b1 7.0 \u03bcmol\u00b7l<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup>, P = 0.003) in response to exercise than U-SCT. Our data indicate that the overall oxidative stress and nitric oxide response is improved in exercise-trained SCT carriers compared with their untrained counterparts. These results suggest that physical activity could be a viable method of controlling the oxidative stress. This could have a beneficial impact because of its involvement in endothelial dysfunction and subsequent vascular impairment in hemoglobin S carriers.<\/jats:p>","DOI":"10.1152\/japplphysiol.01452.2011","type":"journal-article","created":{"date-parts":[[2012,2,11]],"date-time":"2012-02-11T01:49:51Z","timestamp":1328924991000},"page":"1445-1453","source":"Crossref","is-referenced-by-count":45,"title":["Exercise training blunts oxidative stress in sickle cell trait carriers"],"prefix":"10.1152","volume":"112","author":[{"given":"Erica N.","family":"Chirico","sequence":"first","affiliation":[{"name":"Center of Research and Innovation on Sports, University Claude Bernard Lyon 1, University of Lyon, Villeurbanne;"},{"name":"CarMeN, INSERM, University Claude Bernard Lyon 1, Faculty of Medicine Lyon Sud, Oullins;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Martin","sequence":"additional","affiliation":[{"name":"Center of Research and Innovation on Sports, 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