{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T18:23:18Z","timestamp":1770142998209,"version":"3.49.0"},"reference-count":45,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p> Periodic breathing is commonly observed in chronic heart failure (CHF) when pulmonary capillary wedge pressure is abnormally high and there is usually concomitant tachypneic hyperventilation. We hypothesized that acute pulmonary hypertension at pressures encountered in CHF and involving all of the lungs and pulmonary vessels would predispose to apnea\/unstable breathing during sleep. We tested this in a chronically instrumented, unanesthetized dog model during non-rapid eye movement (NREM) sleep. Pulmonary hypertension was created by partial occlusion of the left atrium by means of an implanted balloon catheter in the atrial lumen. Raising mean left atrial pressure by 5.7 \u00b1 1.1 Torr resulted immediately in tachypneic hyperventilation [breathing frequency increased significantly from 13.8 to 19.9 breaths\/min; end-tidal Pco<jats:sub>2<\/jats:sub> (Pet<jats:sub>CO<jats:sub>2<\/jats:sub><\/jats:sub>) fell significantly from 38.5 to 35.9 Torr]. This tachypneic hyperventilation was present during wakefulness, NREM sleep, and rapid eye movement sleep. In NREM sleep, this increase in left atrial pressure increased the gain of the ventilatory response to CO<jats:sub>2<\/jats:sub> below eupnea (1.3 to 2.2 l\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7Torr<jats:sup>\u22121<\/jats:sup>) and thereby narrowed the CO<jats:sub>2<\/jats:sub> reserve [Pet<jats:sub>CO<jats:sub>2<\/jats:sub><\/jats:sub> (apneic threshold) \u2212 Pet<jats:sub>CO<jats:sub>2<\/jats:sub><\/jats:sub> (eupnea)], despite the decreased plant gain resulting from the hyperventilation. We conclude that acute pulmonary hypertension during sleep results in a narrowed CO<jats:sub>2<\/jats:sub> reserve and thus predisposes toward apnea\/unstable breathing and may, therefore, contribute to the breathing instability observed in CHF. <\/jats:p>","DOI":"10.1152\/japplphysiol.01617.2005","type":"journal-article","created":{"date-parts":[[2006,4,20]],"date-time":"2006-04-20T20:47:39Z","timestamp":1145566059000},"page":"76-83","source":"Crossref","is-referenced-by-count":66,"title":["Increased propensity for apnea in response to acute elevations in left atrial pressure during sleep in the dog"],"prefix":"10.1152","volume":"101","author":[{"given":"Bruno J.","family":"Chenuel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curtis A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James B.","family":"Skatrud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen S.","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome A.","family":"Dempsey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1994.266.6.R1951"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.51.5.624"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(81)90050-4"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00749.2004"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a015269"},{"key":"R6","unstructured":"Downing SE. Reflex effects of acute hypertension in the pulmonary vascular bed of the dog. Yale J Biol Med 30: 43\u201356, 1957."},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1971.sp009627"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.74.1.345"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1985.249.2.H393"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.2.8756809"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.67.6.2257"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200507-1035OC"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909233411304"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199608223350805"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1972.sp009965"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1987.sp016869"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1989.sp017450"},{"key":"R19","unstructured":"Kaufman MP and Forster HV. Reflexes controlling circulatory, ventilatory, and airway responses to exercise. In: Handbook of Physiology. Exercise: Regulation and Integration of Multiple Systems. Bethesda, MD: Am. Physiol. Soc. 1996, sect. 12, chapt. 10, p. 381\u2013447."},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.5.ed1101c"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.40.1.64"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.77.5.2079"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019971"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1977.43.1.107"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.61.6.2095"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1978.45.3.385"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1988.65.1.131"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.5.9810040"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00722.2002"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2110041"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.150.6.7952621"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1976.40.5.688"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.24.2418"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.58.4.512"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.6.2004169"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.78.5.1688"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.12.1574"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.86.4.1264"},{"key":"R39","doi-asserted-by":"crossref","unstructured":"Thoren P. Left ventricular receptors activated by severe asphyxia and by coronary artery occlusion. Acta Physiol Scand 85: 455\u2013463, 1972.","DOI":"10.1111\/j.1748-1716.1971.tb05283.x"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.1.408"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.10.70"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.62.3.870"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.00269.x"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200406-807OC"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200110-022OC"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.5.2007013"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.01617.2005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T16:39:54Z","timestamp":1567960794000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/japplphysiol.01617.2005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["10.1152\/japplphysiol.01617.2005"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.01617.2005","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7]]}}}