{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T19:34:27Z","timestamp":1793302467500,"version":"4.5.0"},"reference-count":53,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["NIH R01 HL160997"],"award-info":[{"award-number":["NIH R01 HL160997"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2026,11,1]]},"abstract":"<jats:p>\n                    This study is aimed at providing a mechanistic explanation for the clinical benefits of coronary sinus reducer (CSR) therapy for refractory angina linked to myocardial ischemia. We show that CSR elevates venous pressure, can facilitate retrograde venous perfusion, and helps increase O\n                    <jats:sub>2<\/jats:sub>\n                    transport to severely ischemic myocardium. The findings reveal that CSR efficacy depends on severity of arterial stenosis, venous compliance, and microvascular O\n                    <jats:sub>2<\/jats:sub>\n                    transport dynamics.\n                  <\/jats:p>","DOI":"10.1152\/japplphysiol.90262.2026","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:21:13Z","timestamp":1790875273000},"page":"1252-1272","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of coronary sinus reducer on oxygen transport in myocardial ischemia"],"prefix":"10.1152","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3920-4575","authenticated-orcid":false,"given":"Mythri","family":"Tumbalam Gooty","sequence":"first","affiliation":[{"name":"Michigan State University","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8786-2479","authenticated-orcid":false,"given":"Haifeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Shantou University","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7032-0777","authenticated-orcid":false,"given":"Jenny S.","family":"Choy","sequence":"additional","affiliation":[{"name":"California Medical Innovations Institute","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2266-1603","authenticated-orcid":false,"given":"Sujal Laxmikant","family":"Vajire","sequence":"additional","affiliation":[{"name":"Michigan State University","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7126-1484","authenticated-orcid":false,"given":"Ghassan S.","family":"Kassab","sequence":"additional","affiliation":[{"name":"California Medical Innovations Institute","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lik-Chuan","family":"Lee","sequence":"additional","affiliation":[{"name":"Michigan State University","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACC.2007.01.061"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocmr.2025.101868"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.123.013481"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2023.2566"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s12471-016-0862-2"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1402556"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.17925\/hi.2020.14.1.29"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2025.08.066"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00256-3"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00910.2023"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1177\/153537020523000801"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2023.107908"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2024.108486"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/bf02738551"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1993.265.1.h350"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1994.267.6.h2100"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1994.267.1.h319"},{"key":"B18","volume-title":"Anatomy, Thorax, Heart Arteries","author":"Chaudhry R","year":"2026"},{"key":"B19","volume-title":"Anatomy, Thorax, Heart Thebesian Veins","author":"Nordick K","year":"2026"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2353(200103)14:2<102::AID-CA1018>3.0.CO;2-4"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1159\/000144450"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/FPHYS.2020.00915"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/JAPPLPHYSIOL.00450.2019"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01184.2011"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201711795"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.112.972224"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00857.2011"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.21037\/qims-21-987"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1114\/1.1359450"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1364\/OE.16.17530"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa023"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/AJPHEART.1982.242.2.H240"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1007\/BF01906385"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23566"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV9I10A196"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2024.05.006"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1007\/S10439-012-0583-7\/FIGURES\/3"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1152\/AJPHEART.1995.268.4.H1675"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.4244\/eij-d-18-00102"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00063.2008"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.79.2.479"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.82.12.1312"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.275.5.h1663"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.200910276"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00380.2003"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3389\/FPHYS.2021.744855\/FULL"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.mechrescom.2019.04.008"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1991.260.1.h146"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-018-9793-1"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1992.263.6.H1770"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.crhy.2013.04.002"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00730.2004"},{"key":"B53","volume-title":"Cardiovascular Physiology Concepts","author":"Richard K","year":"2021","edition":"3"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.90262.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T19:19:50Z","timestamp":1793301590000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/japplphysiol.90262.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11,1]]},"references-count":53,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,11,1]]}},"alternative-id":["10.1152\/japplphysiol.90262.2026"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.90262.2026","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,11,1]]},"assertion":[{"value":"2026-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-11","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}