{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:10:26Z","timestamp":1791245426012,"version":"4.1.0"},"reference-count":54,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:p> Our previous work showed a diminished cerebral blood flow (CBF) response to changes in Pa<jats:sub>CO<jats:sub>2<\/jats:sub><\/jats:sub> in congestive heart failure patients with central sleep apnea compared with those without apnea. Since the regulation of CBF serves to minimize oscillations in H<jats:sup>+<\/jats:sup> and Pco<jats:sub>2<\/jats:sub> at the site of the central chemoreceptors, it may play an important role in maintaining breathing stability. We hypothesized that an attenuated cerebrovascular reactivity to changes in Pa<jats:sub>CO<jats:sub>2<\/jats:sub><\/jats:sub> would narrow the difference between the eupneic Pa<jats:sub>CO<jats:sub>2<\/jats:sub><\/jats:sub> and the apneic threshold Pa<jats:sub>CO<jats:sub>2<\/jats:sub><\/jats:sub> (\u0394Pa<jats:sub>CO<jats:sub>2<\/jats:sub><\/jats:sub>), known as the CO<jats:sub>2<\/jats:sub> reserve, thereby making the subjects more susceptible to apnea. Accordingly, in seven normal subjects, we used indomethacin (Indo; 100 mg by mouth) sufficient to reduce the CBF response to CO<jats:sub>2<\/jats:sub> by \u223c25% below control. The CO<jats:sub>2<\/jats:sub> reserve was estimated during non-rapid eye movement (NREM) sleep. The apnea threshold was determined, both with and without Indo, in NREM sleep, in a random order using a ventilator in pressure support mode to gradually reduce Pa<jats:sub>CO<jats:sub>2<\/jats:sub><\/jats:sub> until apnea occurred. results: Indo significantly reduced the CO<jats:sub>2<\/jats:sub> reserve required to produce apnea from 6.3 \u00b1 0.5 to 4.4 \u00b1 0.7 mmHg ( P = 0.01) and increased the slope of the ventilation decrease in response to hypocapnic inhibition below eupnea (control vs. Indo: 1.06 \u00b1 0.10 vs. 1.61 \u00b1 0.27 l\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7mmHg<jats:sup>\u22121<\/jats:sup>, P &lt; 0.05). We conclude that reductions in the normal cerebral vascular response to hypocapnia will increase the susceptibility to apneas and breathing instability during sleep. <\/jats:p>","DOI":"10.1152\/japplphysiol.90914.2008","type":"journal-article","created":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T01:34:20Z","timestamp":1230773660000},"page":"850-856","source":"Crossref","is-referenced-by-count":63,"title":["Influence of cerebral blood flow on breathing stability"],"prefix":"10.1152","volume":"106","author":[{"given":"Ailiang","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Skatrud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Barczi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Reichmuth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara J.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Mont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome A.","family":"Dempsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00911.2006"},{"key":"R2","unstructured":"Berend N, Christopher KL, Voelkel NF. 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