{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T14:00:51Z","timestamp":1780322451431,"version":"3.54.1"},"reference-count":53,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:p>Recent studies suggest a link between exercise-induced rhabdomyolysis and mutations of the ryanodine receptor (RYR1) associated with malignant hyperthermia (MH). We hypothesized that MH-susceptible mice (RYR1<jats:sup>Y522S\/wt<\/jats:sup>) would exhibit greater anterior crural muscle [tibialis anterior (TA) and extensor digitorum longus (EDL) muscles] damage and strength deficits following the performance of a single or repeated bouts of eccentric contractions compared with wild-type (WT) mice. After a single injury bout, RYR1<jats:sup>Y522S\/wt<\/jats:sup>mice produced more isometric torque than WT mice immediately and 3 and 7 days postinjury. Moreover, EDL muscle isometric specific force deficits were fully recovered for RYR1<jats:sup>Y522S\/wt<\/jats:sup>but not WT mice 14 days postinjury. The percentage of fibers in TA muscle exhibiting signs of muscle damage 7 and 14 days postinjury were at least three times less in RYR1<jats:sup>Y522S\/wt<\/jats:sup>than in WT mice. Uninjured and injured EDL muscle from RYR1<jats:sup>Y522S\/wt<\/jats:sup>mice also displayed greater S-glutathionylation of RYR1 than that from WT mice. During the weekly injury bouts, torque production by RYR1<jats:sup>Y522S\/wt<\/jats:sup>mice was fully recovered before the third and fourth injury bouts, whereas torque was still reduced for WT mice. Three days after multiple injury bouts, there were \u223c50% fewer fibers exhibiting signs of muscle damage in RYR1<jats:sup>Y522S\/wt<\/jats:sup>than in WT TA muscle. These findings indicate that the RYR1<jats:sup>Y522S\/wt<\/jats:sup>mutation protects skeletal muscle from exercise-induced muscle injury and do not support a direct association between MH susceptibility and contraction-induced rhabdomyolysis when core temperature is maintained at lower physiological temperatures during exercise.<\/jats:p>","DOI":"10.1152\/japplphysiol.90926.2008","type":"journal-article","created":{"date-parts":[[2008,9,12]],"date-time":"2008-09-12T00:56:21Z","timestamp":1221180981000},"page":"1542-1553","source":"Crossref","is-referenced-by-count":28,"title":["Eccentric contractions do not induce rhabdomyolysis in malignant hyperthermia susceptible mice"],"prefix":"10.1152","volume":"105","author":[{"given":"Benjamin T.","family":"Corona","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clement","family":"Rouviere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P.","family":"Ingalls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306969200"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M600876200"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2004.08.001"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1995.sp020943"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.5414\/CNP60296"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-4497fje"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200737040-00022"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2005.03.010"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1023\/A:1017124817798"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(01)01250-0"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/88.4.508"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.067876"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(00)76290-4"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1990.68.3.1241"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M403612200"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.02.042"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.43.25557"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107134200"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/85.1.118"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005368831198"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.1.58"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00084.2003"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01058.2003"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-201X.2004.01271.x"},{"key":"R25","doi-asserted-by":"crossref","unstructured":"Kochling A, Wappler F, Winkler G, Schulte am Esch JS.Rhabdomyolysis following severe physical exercise in a patient with predisposition to malignant hyperthermia.Anaesth Intensive Care26: 315\u2013318, 1998.","DOI":"10.1177\/0310057X9802600317"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.80.1.278"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.79.4.1260"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4160(97)90022-1"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.61.1.293"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(93)90130-Q"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0838.2003.02477.x"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1097\/00006565-199712000-00006"},{"key":"R33","doi-asserted-by":"crossref","unstructured":"Muldoon S, Deuster P, Brandom B, Bunger R.Is there a link between malignant hyperthermia and exertional heat illness?Exerc Sport Sci Rev32: 174\u2013179, 2004.","DOI":"10.1097\/00003677-200410000-00009"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(01)00635-9"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.01273.2000"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.035204"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-1809.2000.6440307.x"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-21"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-8180(96)00207-3"},{"key":"R40","unstructured":"Sharma N, Winpenny H, Heymann T.Exercise-induced rhabdomyolysis: even the fit may suffer.Int J Clin Pract53: 476\u2013477, 1999."},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01503.2005"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1177\/0095399703258788"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200101000-00019"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.81.6.2555"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019645"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00671.2001"},{"key":"R47","doi-asserted-by":"publisher","DOI":"10.1097\/00003677-200104000-00008"},{"key":"R48","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.609ac.x"},{"key":"R49","doi-asserted-by":"publisher","DOI":"10.1006\/pmed.2001.0909"},{"key":"R50","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.075275"},{"key":"R51","doi-asserted-by":"crossref","unstructured":"Zaidi NF, Lagenaur CF, Abramson JJ, Pessah I, Salama G.Reactive disulfides trigger Ca2+release from sarcoplasmic reticulum via an oxidation reaction.J Biol Chem264: 21725\u201321736, 1989.","DOI":"10.1016\/S0021-9258(20)88246-5"},{"key":"R52","doi-asserted-by":"publisher","DOI":"10.1086\/508500"},{"key":"R53","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm096"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.90926.2008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T09:09:40Z","timestamp":1631783380000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/japplphysiol.90926.2008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":53,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["10.1152\/japplphysiol.90926.2008"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.90926.2008","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11]]}}}