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The present study investigated the use of both near-infrared spectroscopy (NIRS) measurements of the cerebral metabolic rate of oxygen (CMRO<jats:sub>2<\/jats:sub>) and amplitude-integrated EEG (aEEG) to detect the severity of hypoxia-ischemia after 1 h of reperfusion in newborn piglets (10 insult, 3 control). The CMRO<jats:sub>2<\/jats:sub> was measured before and after 1 h of reperfusion from hypoxia-ischemia, the duration of which was varied from piglet to piglet with a range of 3\u201324 min, under fentanyl\/nitrous oxide anesthesia to mimic awake-like levels of cerebral metabolism. EEG data were collected throughout the study. On average, the CMRO<jats:sub>2<\/jats:sub> and mean aEEG background signals were significantly depressed following the insult ( P &lt; 0.05). Mean CMRO<jats:sub>2<\/jats:sub> and mean aEEG background were 2.61 \u00b1 0.11 ml O<jats:sub>2<\/jats:sub>\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7100 g<jats:sup>\u22121<\/jats:sup> and 20.4 \u00b1 2.7 \u03bcV before the insult and 1.58 \u00b1 0.09 ml O<jats:sub>2<\/jats:sub>\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b7100 g<jats:sup>\u22121<\/jats:sup> and 11.8 \u00b1 2.9 \u03bcV after 1 h of reperfusion, respectively. Both CMRO<jats:sub>2<\/jats:sub> and aEEG displayed statistically significant correlations with duration of ischemia ( P &lt; 0.05; r = 0.71 and r = 0.89, respectively); however, only CMRO<jats:sub>2<\/jats:sub> was sensitive to milder injuries (&lt;5 min). This study highlights the potential for combining NIRS measures of CMRO<jats:sub>2<\/jats:sub> with EEG in the neonatal intensive care unit to improve early detection of perinatal hypoxia-ischemia. <\/jats:p>","DOI":"10.1152\/japplphysiol.91156.2008","type":"journal-article","created":{"date-parts":[[2009,3,20]],"date-time":"2009-03-20T01:42:08Z","timestamp":1237513328000},"page":"1506-1512","source":"Crossref","is-referenced-by-count":27,"title":["Cerebral metabolic rate of oxygen and amplitude-integrated electroencephalography during early reperfusion after hypoxia-ischemia in piglets"],"prefix":"10.1152","volume":"106","author":[{"given":"Kenneth M.","family":"Tichauer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan T.","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer A.","family":"Hadway","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Yim","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"St. Lawrence","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.103.6.1263"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.04.119"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000090928.93045.BE"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200205000-00004"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(02)01112-7"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1007\/s003810000391"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70349-X"},{"key":"R8","unstructured":"Cenic A, Nabavi DG, Craen RA, Gelb AW, Lee TY. 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