{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:33:50Z","timestamp":1791110030083,"version":"4.1.0"},"reference-count":39,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:p> Full expression of reflex cutaneous vasodilation is dependent on cyclooxygenase- (COX) and nitric oxide synthase- (NOS) dependent mechanisms. Low-dose aspirin therapy is widely prescribed to inhibit COX-1 in platelets for atherothrombotic prevention. We hypothesized that chronic COX inhibition with daily low-dose aspirin therapy (81 mg) would attenuate reflex vasodilation in healthy human skin. Two microdialysis fibers were placed in forearm skin of seven middle-aged (57 \u00b1 3 yr), normotensive, healthy humans with no preexisting cardiovascular disease, taking daily low-dose aspirin therapy (aspirin: 81 mg), and seven unmedicated, healthy, age-matched control (no aspirin, 55 \u00b1 3 yr) subjects, with one site serving as a control (Ringer) and the other NOS inhibited (NOS inhibited: 10 mM N<jats:sup>G<\/jats:sup>-nitro-l-arginine methyl ester). Red cell flux was measured over each site by laser-Doppler flowmetry, as reflex vasodilation was induced by increasing core temperature (oral temperature) 1.0\u00b0C using a water-perfused suit. Cutaneous vascular conductance (CVC) was calculated (CVC = flux\/mean arterial pressure) and normalized to maximal CVC (CVC<jats:sub>max<\/jats:sub>; 28 mM sodium nitroprusside). CVC<jats:sub>max<\/jats:sub> was not affected by either aspirin or NOS inhibition. The plateau in cutaneous vasodilation during heating (change in oral temperature = 1.0\u00b0C) was significantly attenuated in the aspirin group (aspirin: 25 \u00b1 3% CVC<jats:sub>max<\/jats:sub> vs. no aspirin: 50 \u00b1 7% CVC<jats:sub>max<\/jats:sub>, P &lt; 0.001 between groups). NOS inhibition significantly attenuated %CVC<jats:sub>max<\/jats:sub> in both groups (aspirin: 17 \u00b1 2% CVC<jats:sub>max<\/jats:sub>, no aspirin: 23 \u00b1 3% CVC<jats:sub>max<\/jats:sub>; P &lt; 0.001 vs. control), but this attenuation was less in the no-aspirin treatment group ( P &lt; 0.001). This is the first observation that chronic low-dose aspirin therapy attenuates reflex cutaneous vasodilation through both COX- and NOS-dependent mechanisms. <\/jats:p>","DOI":"10.1152\/japplphysiol.91215.2008","type":"journal-article","created":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T20:56:27Z","timestamp":1227732987000},"page":"500-505","source":"Crossref","is-referenced-by-count":27,"title":["Chronic low-dose aspirin therapy attenuates reflex cutaneous vasodilation in middle-aged humans"],"prefix":"10.1152","volume":"106","author":[{"given":"Lacy A.","family":"Holowatz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Larry","family":"Kenney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.042135"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00558267"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1007\/s002280050539"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.279.3.R839"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200342120-00004"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.276.5.H1634"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2007.01.003"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.63.2.306"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1038\/318186a0"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00871.2002"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00295.2007"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.128959"},{"key":"R13","doi-asserted-by":"crossref","unstructured":"Holowatz LA, Thompson-Torgerson CS, Kenney WL. Altered mechanisms of vasodilation in aged human skin. Exerc Sport Sci Rev 35: 119\u2013125, 2007.","DOI":"10.1097\/jes.0b013e3180a02f85"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00648.2006"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.080952"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.12.10.1206"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.3.824"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.86.4.1185"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.77.6.1222"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.75.5.1025"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111110"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00359.2005"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01217.2006"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.4.1619"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00229.2002"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(96)00019-8"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.72.6.1177"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.1_suppl.39S"},{"key":"R29","unstructured":"Patrono C, Rocca B. Aspirin: promise and resistance in the new millennium. Arterioscler Thromb 28: s25\u2013s32, 2008."},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198411083111902"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1957.sp005775"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00810.2007"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.3.830"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1984.57.1.191"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000074879.19006.51"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.112508"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00254.2003"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.071779"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00639.2003"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.91215.2008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T18:24:23Z","timestamp":1567967063000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/japplphysiol.91215.2008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.1152\/japplphysiol.91215.2008"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.91215.2008","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}