{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:19:11Z","timestamp":1773422351537,"version":"3.50.1"},"reference-count":35,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:p> Microdialysis enables in-depth mechanistic study of the cutaneous circulation in humans. However, whether the insertion or presence of the microdialysis fiber (MDF) affects the skin circulation or its responses is unknown. We tested whether the cutaneous vascular response to whole body heating (WBH) was affected by MDF or by pretreatment with ice ( part 1) or local anesthesia (LA; part 2). Eleven subjects participated, 9 in part 1 and 8 in part 2 (5 participated in both). In both parts, four sites on the forearm were selected, providing untreated control, MDF only, ice or LA only, and combined MDF plus ice or LA. A tube-lined suit controlled whole body skin temperature, which was raised to \u223c38\u00b0C for WBH. Skin sites were instrumented with laser-Doppler flow probes. Data were expressed as cutaneous vascular conductance (CVC). Baseline levels were not different among sites ( P &gt; 0.05). In part 1, the internal temperature for the onset of vasodilation was higher ( P &gt; 0.05) with MDF with or without ice pretreatment than at untreated control sites (control 36.6 \u00b1 0.1\u00b0C, Ice 36.5 \u00b1 0.1, MDF 36.8 \u00b1 0.1\u00b0C, and Ice+MDF 36.8 \u00b1 0.1\u00b0C). Peak CVC during WBH was decreased ( P &lt; 0.05) by MDF (control 73 \u00b1 7 vs. MDF 59 \u00b1 6% of maximal CVC). Ice (73 \u00b1 6% of maximal CVC) or Ice+MDF (69 \u00b1 6% of maximal CVC) did not affect ( P &gt; 0.05) peak CVC compared with control. In part 2, the temperature threshold for the onset of vasodilation was increased by MDF with or without LA treatment and by LA alone ( P &lt; 0.05; control 36.6 \u00b1 0.1\u00b0C, MDF 36.7 \u00b1 0.1\u00b0C, LA 36.8 \u00b1 0.1\u00b0C, and LA+MDF 36.8 \u00b1 0.1\u00b0C). Peak CVC was decreased by MDF (control 69 \u00b1 6% of maximal CVC vs. MDF 58 \u00b1 8% of maximal CVC; P &lt; 0.05). LA only (65 \u00b1 10% of maximal CVC) or MDF in the presence of LA (73 \u00b1 12% of maximal CVC) did not affect ( P &gt; 0.05) peak CVC compared with control. Thus LA or MDF increases the temperature threshold for the onset of vasodilation. MDF alone decreases the peak vasodilator response in CVC to WBH; however, this attenuation did not occur if ice or LA is used before MDF placement. Ice or LA alone do not affect the peak response in CVC to WBH. How those treatments prevent or reverse the effect of MDF placement is presently unclear. <\/jats:p>","DOI":"10.1152\/japplphysiol.91508.2008","type":"journal-article","created":{"date-parts":[[2009,2,6]],"date-time":"2009-02-06T23:47:50Z","timestamp":1233964070000},"page":"1112-1118","source":"Crossref","is-referenced-by-count":79,"title":["The effect of microdialysis needle trauma on cutaneous vascular responses in humans"],"prefix":"10.1152","volume":"106","author":[{"given":"Gary J.","family":"Hodges","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech A.","family":"Kosiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01265.2005"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12378630"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1990.tb00324.x"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.1.381"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2006.11.069"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1997.273.2.H1038"},{"key":"R7","unstructured":"Groth L, J\u00f8rgensen A, Serup J. Cutaneous microdialysis in the rat: insertion trauma and effect of anaesthesia studied by laser Doppler perfusion imaging and histamine. Skin Pharmacol Appl Skin Physiol 111: 125\u2013132, 1998."},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00815.2007"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90412.2008"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00919.2008"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00323.2007"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.109884"},{"key":"R13","unstructured":"Johnson JM. The cutaneous circulation. In: Laser-Doppler Blood Flowmetry, edited by Shepherd AP and \u00d6berg PA. New York: Springer, 1990, p. 121\u2013139."},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.1986.tb00239.x"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00849.2004"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.86.4.1185"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.144642"},{"key":"R18","unstructured":"Lewis T. The Blood Vessels of the Human Skin and Their Responses. London: Shaw & Sons, 1927."},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1987.253.2.E228"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.4.1619"},{"key":"R21","doi-asserted-by":"crossref","unstructured":"Minson CT, Holowatz LA, Wong BJ, Kenney WL, Wilkins BW. Decreased nitric oxide- and axon reflex-mediated cutaneous vasodilation with age during local heating. J Appl Physiol 9: 1644\u20131649, 2002.","DOI":"10.1152\/japplphysiol.00229.2002"},{"key":"R22","unstructured":"\u00d6berg PA. Laser-Doppler flowmetry. Crit Rev Biomed Eng 18: 125\u2013163, 1990."},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.13.6.647"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1988.65.1.478"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00061.2004"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00600.2007"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.66.4.1586"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1984.57.1.191"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00839.2004"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.065714"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00366.2004"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.112508"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.095372"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.071779"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00139.2005"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.91508.2008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T17:37:08Z","timestamp":1567964228000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/japplphysiol.91508.2008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["10.1152\/japplphysiol.91508.2008"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.91508.2008","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4]]}}}