{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:40:16Z","timestamp":1787240416759,"version":"build-2736575974"},"reference-count":31,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:p>During sudden or too rapid decompression, gas is released within supersaturated tissues in the form of bubbles, the cause of decompression sickness. It is widely accepted that these bubbles originate in the tissue from preexisting gas micronuclei. Pretreatment with hyperbaric oxygen (HBO) has been hypothesized to shrink the gas micronuclei, thus reducing the number of emerging bubbles. The effectiveness of a new HBO pretreatment protocol on neurologic outcome was studied in rats. This protocol was found to carry the least danger of oxygen toxicity. Somatosensory evoked potentials (SSEPs) were chosen to serve as a measure of neurologic damage. SSEPs in rats given HBO pretreatment before a dive were compared with SSEPs from rats not given HBO pretreatment and SSEPs from non-dived rats. The incidence of abnormal SSEPs in the animals subjected to decompression without pretreatment (1,013 kPa for 32 min followed by decompression) was 78%. In the pretreatment group (HBO at 304 kPa for 20 min followed by exposure to 1,013 kPa for 33 min and decompression) this was significantly reduced to 44%. These results call for further study of the pretreatment protocol in higher animals.<\/jats:p>","DOI":"10.1152\/japplphysiol.91557.2008","type":"journal-article","created":{"date-parts":[[2009,5,21]],"date-time":"2009-05-21T21:26:04Z","timestamp":1242941164000},"page":"558-563","source":"Crossref","is-referenced-by-count":8,"title":["Hyperbaric oxygen pretreatment according to the gas micronuclei denucleation hypothesis reduces neurologic deficit in decompression sickness in rats"],"prefix":"10.1152","volume":"107","author":[{"given":"K.","family":"Katsenelson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Arieli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Arieli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Abramovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Feinsod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Tal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(81)90008-X"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Arieli R\n                      , Boaron E, Abramovich A.\n                      The combined effect of denucleation and denitrogenation on the risk of decompression sickness in rats.\n                      J Appl Physiol\n                      106\n                      : 1453\u20131458, 2008.","DOI":"10.1152\/japplphysiol.91146.2008"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01059.2001"},{"key":"R4","unstructured":"Arieli Y\n                      , Katsenelson K, Arieli R.\n                      Bubble reduction after decompression in the prawn\n                      Palaemon elegans\n                      by pretreatment with hyperbaric oxygen.\n                      Undersea Hyperb Med\n                      34\n                      : 369\u2013378, 2007."},{"key":"R5","unstructured":"Bennett PB\n                      , Elliott DH (editors).\n                      The Physiology and Medicine of Diving\n                      (4th ed.). London: Saunders, 1993."},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1016\/0168-5597(90)90024-8"},{"key":"R7","unstructured":"Conkin J\n                      , Schuhmann RE.\n                      Decrease of ether induction time after exposure to dysbaric conditions in rat.\n                      Undersea Biomed Res\n                      10\n                      : 343\u2013348, 1983."},{"key":"R8","unstructured":"Elliott DH\n                      , Moon RE.\n                      Manifestations of the decompression disorders. In:\n                      The Physiology and Medicine of Diving\n                      (4th ed.), edited by Bennett PB and Elliott DH. London: Saunders, 1993, p. 481\u2013505."},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01051.2004"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1038\/222251a0"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.38.11.1109"},{"key":"R12","unstructured":"Francis TJR\n                      , Gorman DF.\n                      Pathogenesis of the decompression disorders. In:\n                      The Physiology and Medicine of Diving\n                      (4th ed.), edited by Bennett PB and Elliott DH. 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New York: McGraw-Hill, 2000."},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-007-0528-2"},{"key":"R17","unstructured":"Khan T\n                      , Havey RM, Sayers ST, Patwardhan A, King WW.\n                      Animal models of spinal cord contusion injuries.\n                      Lab Anim Sci\n                      49\n                      : 161\u2013172, 1999."},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1007\/s11332-006-0022-y"},{"key":"R19","unstructured":"Latson G\n                      , Flynn E, Gerth W, Thalmann E, Maurer J, Lowe M.\n                      Accelerated Decompression Using Oxygen for Submarine Rescue\u2014Summary Report and Operational Guidance.\n                      Panama City, FL: Navy Experimental Diving Unit, 2000. (NEDU Technical Report no. 11\u201300)."},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.89.6.2107"},{"key":"R21","unstructured":"Mahon RT\n                      , Dainer HM, Nelson JW.\n                      Decompression sickness in a swine model: isobaric denitrogenation and perfluorocarbon at depth.\n                      Aviat Space Environ Med\n                      77\n                      : 8\u201312, 2006."},{"key":"R22","unstructured":"Martin JD\n                      , Thom SR.\n                      Vascular leukocyte sequestration in decompression sickness and prophylactic hyperbaric oxygen therapy in rats.\n                      Aviat Space Environ Med\n                      73\n                      : 565\u2013569, 2002."},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1007\/BF00866918"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199205000-00005"},{"key":"R25","unstructured":"Pilmanis AA\n                      , Balldin UI, Webb JT, Krause KM.\n                      Staged decompression to 3.5 psi using argon-oxygen and 100% oxygen breathing mixtures.\n                      Aviat Space Environ Med\n                      74\n                      : 1243\u20131250, 2003."},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1016\/0168-5597(91)90085-C"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-5629(02)00683-X"},{"key":"R28","unstructured":"Tikuisis P\n                      , Gerth WA.\n                      Decompression theory. In:\n                      Bennett and Elliott's Physiology and Medicine of Diving\n                      (5th ed.), edited by Brubakk AO and Neuman TS. Edinburgh, UK: Saunders, 2003, p. 419\u2013454."},{"key":"R29","unstructured":"Vann RD\n                      , Grimstad J, Nielsen CH.\n                      Evidence for gas nuclei in decompressed rats.\n                      Undersea Biomed Res\n                      7\n                      : 107\u2013112, 1980."},{"key":"R30","doi-asserted-by":"crossref","unstructured":"Walsh P\n                      , Kane N, Butler S.\n                      The clinical role of evoked potentials.\n                      J Neurol Neurosurg Psychiatry\n                      76,\n                      Suppl\n                      2\n                      : ii16\u2013ii22, 2005.","DOI":"10.1136\/jnnp.2005.068130"},{"key":"R31","unstructured":"Webb JT\n                      , Pilmanis AA.\n                      Preoxygenation time versus decompression sickness incidence.\n                      SAFE J\n                      29\n                      : 75\u201378, 1999."}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.91557.2008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T17:42:05Z","timestamp":1567964525000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/japplphysiol.91557.2008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["10.1152\/japplphysiol.91557.2008"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.91557.2008","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8]]}}}