{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T03:04:54Z","timestamp":1782529494822,"version":"3.54.5"},"reference-count":76,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["CIHR PJT 165987"],"award-info":[{"award-number":["CIHR PJT 165987"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["CIHR PJT 183970"],"award-info":[{"award-number":["CIHR PJT 183970"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:p>This study provides direct evidence of motor learning-related plasticity in a cortical circuit involving sensory areas in rostral parietal cortex and premotor areas in frontal cortex. Using a visuomotor adaptation paradigm with cTBS, disruption of rostral parietal or dorsal premotor cortex impairs retention, whereas disruption of primary motor cortex does not. Disrupting both regions together causes no additional impairment, suggesting an interconnected learning circuit in humans and advancing understanding of cortical substrates of motor learning.<\/jats:p>","DOI":"10.1152\/jn.00009.2026","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T01:10:49Z","timestamp":1775783449000},"page":"1175-1185","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Human motor memory retention requires fronto-parietal circuit plasticity"],"prefix":"10.1152","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7539-1286","authenticated-orcid":false,"given":"Shahryar","family":"Ebrahimi","sequence":"first","affiliation":[{"name":"McGill University","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Darainy","sequence":"additional","affiliation":[{"name":"McGill University","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy F.","family":"Manning","sequence":"additional","affiliation":[{"name":"McGill University","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5950-4865","authenticated-orcid":false,"given":"Emmett","family":"Lewis-Hoeber","sequence":"additional","affiliation":[{"name":"McGill University","place":["Canada"]},{"name":"McGill University","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7427-6526","authenticated-orcid":false,"given":"David J.","family":"Ostry","sequence":"additional","affiliation":[{"name":"McGill University","place":["Canada"]},{"name":"Yale Child Study Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.0629-24.2024"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2316294121"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00231.2023"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000469"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.55241"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2204379119"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphysparis.2006.03.007"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.11.020"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.11-05-01182.1991"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1993.70.5.2097"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.84.1.152"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.02-09-01329.1982"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.1300-24.2024"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3386-05.2006"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.051508.135409"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s002210050832"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/6.3.319"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/s0959-4388(97)80146-8"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-10-72"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000001838"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq260"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901830410"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19981221)402:3<327::AID-CNE4>3.0.CO;2-Z"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902280110"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-002-1078-9"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902620207"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24453"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3902-04.2005"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.11-03-00667.1991"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902590309"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901810206"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903450203"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1007\/BF00228864"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00164.2022"},{"key":"B35","unstructured":"Ebrahimi S.\n                      Neural Mechanisms Underlying Human Motor Memory; A Somatosensory Cortex Perspective\n                      (Dissertation). Canada: McGill University, 2024."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/382805a0"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-025-08528-4"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2011.07924.x"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2012.05.001"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1997.0271"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0858"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.12.017"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-018-1798-7"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2019.00062"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012547626-3\/50026-0"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00661.2002"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2016.01.064"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00719.2012"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00383.2019"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1608132114"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.01.027"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.01.019"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12291"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5491.533"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/nature08389"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/nature08577"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1038\/nature15257"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3440-03.2004"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-02-00785.1996"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)91029-8"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2024.137753"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.02.049"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-072116-031407"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114191"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2570-07.2007"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3916-16.2017"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq192"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1139-06.2006"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2004.01.033"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07090.x"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1038\/nature712"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1851-05.2005"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bht346"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2006.18.12.2167"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.12.033"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/s0959-4388(01)00266-5"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/jn.00009.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T14:55:20Z","timestamp":1776869720000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/jn.00009.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,1]]},"references-count":76,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,1]]}},"alternative-id":["10.1152\/jn.00009.2026"],"URL":"https:\/\/doi.org\/10.1152\/jn.00009.2026","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,1]]},"assertion":[{"value":"2026-01-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-04","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}