{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T06:32:34Z","timestamp":1785220354836,"version":"3.55.0"},"reference-count":57,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL148030"],"award-info":[{"award-number":["R01HL148030"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32HL134621"],"award-info":[{"award-number":["T32HL134621"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL149800"],"award-info":[{"award-number":["R01HL149800"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2023,4,1]]},"abstract":"<jats:p> Mild inflammation undermines motor plasticity elicited by mAIH. In a model of mAIH-induced respiratory motor plasticity (phrenic long-term facilitation; pLTF), we report that inflammation induced by low-dose lipopolysaccharide undermines mAIH-induced pLTF by a mechanism requiring increased cervical spinal adenosine and adenosine 2 A receptor activation. This finding advances the understanding of mechanisms impairing neuroplasticity, potentially undermining the ability to compensate for the onset of lung\/neural injury or to harness mAIH as a therapeutic modality. <\/jats:p>","DOI":"10.1152\/jn.00035.2023","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T13:02:11Z","timestamp":1678280531000},"page":"799-806","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Mild inflammation impairs acute intermittent hypoxia-induced phrenic long-term facilitation by a spinal adenosine-dependent mechanism"],"prefix":"10.1152","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7957-6034","authenticated-orcid":false,"given":"Alexandria B.","family":"Marciante","sequence":"first","affiliation":[{"name":"Breathing Research and Therapeutics Center, Department of Physical Therapy & McKnight Brain Institute, University of Florida, Gainesville, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8489-1861","authenticated-orcid":false,"given":"Gordon S.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Breathing Research and Therapeutics Center, Department of Physical Therapy & McKnight Brain Institute, University of Florida, Gainesville, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00523.2002"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00235.2015"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00012.2013"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2021.113891"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2011.06.017"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5472.1765"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2009.05.004"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.10.066"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2008.06.005"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01347.2012"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2011.02.008"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/s0034-5687(00)00124-9"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.90.6.2466"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.26.041002.131103"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2008.07.008"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-5692-7_45"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12085"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-91534-2.00016-3"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00060.2012"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4122-15.2016"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.180075"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00393.2017"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1113\/JP276731"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2016.09.018"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00378.2017"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4539-14.2015"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00619.2016"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2008.01.006"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2004.01976.x"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22517"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2005.08.004"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02074-6"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22179-z"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.0509i.x"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-14-06239.2002"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2008.03.005"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1080\/10790268.2016.1142137"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1177\/1545968319872992"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.09.067"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-006-0135-z"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5714-08.2009"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2009.131"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134488"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1981.241.2.H235"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2004.02.004"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.12.085"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01113.2018"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00098.2012"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2015.00002"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2021.113726"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.6.2831"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2019.02.006"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00476.2003"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/s1569-9048(02)00038-1"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/s1569-9048(03)00086-7"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.114850"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0433-17.2017"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/jn.00035.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T14:51:10Z","timestamp":1680533470000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/jn.00035.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,1]]},"references-count":57,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4,1]]}},"alternative-id":["10.1152\/jn.00035.2023"],"URL":"https:\/\/doi.org\/10.1152\/jn.00035.2023","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,1]]},"assertion":[{"value":"2023-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-23","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}