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Here, we have identified the Na<jats:sub>V<\/jats:sub>1 necessary for AP conduction in the entire murine and rat vagus nerve. We show TTX-sensitive channels are essential for all AP conduction, predominantly Na<jats:sub>V<\/jats:sub>1.7 with Na<jats:sub>V<\/jats:sub>1.2 and Na<jats:sub>V<\/jats:sub>1.6 playing lesser roles depending on the species and fiber type. In addition, we show that Na<jats:sub>V<\/jats:sub>1.8 is also essential for most axonal AP conduction. <\/jats:p>","DOI":"10.1152\/jn.00041.2023","type":"journal-article","created":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T08:00:46Z","timestamp":1692172846000},"page":"684-693","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Action potential conduction in the mouse and rat vagus nerve is dependent on multiple voltage-gated sodium channels (Na<sub>V<\/sub>1s)"],"prefix":"10.1152","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1510-1010","authenticated-orcid":false,"given":"Sanjay S.","family":"Nair","sequence":"first","affiliation":[{"name":"Department of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United 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