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In the present study we evaluated the influence of sound frequency on a derived component of the ABR known as the binaural interaction component (BIC). Specifically, we evaluated the effect of acoustic interaural (between-ear) frequency mismatch on BIC amplitude. Goals were to 1) increase basic understanding of sound features that influence this long-studied auditory potential and 2) gain insight about the persistence of the BIC with interaural electrode mismatch in human users of bilateral cochlear implants, presently a limitation on the prospective utility of the BIC in audiological settings. Data were collected in an animal model that is audiometrically similar to humans, the chinchilla ( Chinchilla lanigera; 6 females). Frequency disparities and amplitudes of acoustic stimuli were varied over broad ranges, and associated variation of BIC amplitude was quantified. Subsequently, responses were simulated with the use of established models of the brain stem pathway thought to underlie the BIC. Collectively, the data demonstrate that at high sound intensities (\u226585 dB SPL), the acoustically elicited BIC persisted with interaurally disparate stimulation (click frequencies \u22651.5 octaves apart). However, sharper tuning emerged at moderate sound intensities (65 dB SPL), with the largest BIC occurring for stimulus frequencies within ~0.8 octaves, equivalent to\u2009\u00b11 mm in cochlear place. Such responses were consistent with simulated responses of the presumed brain stem generator of the BIC, the lateral superior olive. The data suggest that leveraging focused electrical stimulation strategies could improve BIC-based bilateral cochlear implant fitting outcomes.<\/jats:p><jats:p>NEW &amp; NOTEWORTHY Traditional hearing tests evaluate each ear independently. Diagnosis and treatment of binaural hearing dysfunction remains a basic challenge for hearing clinicians. We demonstrate in an animal model that the prospective utility of a noninvasive electrophysiological signature of binaural function, the binaural interaction component (BIC), depends strongly on the intensity of auditory stimulation. Data suggest that more informative BIC measurements could be obtained with clinical protocols leveraging stimuli restricted in effective bandwidth.<\/jats:p>","DOI":"10.1152\/jn.00057.2019","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T20:00:28Z","timestamp":1563393628000},"page":"1110-1122","source":"Crossref","is-referenced-by-count":15,"title":["Between-ear sound frequency disparity modulates a brain stem biomarker of binaural hearing"],"prefix":"10.1152","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0838-2894","authenticated-orcid":false,"given":"Andrew D.","family":"Brown","sequence":"first","affiliation":[{"name":"Department of Speech and Hearing Sciences, University of Washington, Seattle, Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelsey L.","family":"Anbuhl","sequence":"additional","affiliation":[{"name":"Center for Neural Science, New York University, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse I.","family":"Gilmer","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, Colorado"},{"name":"Neuroscience Training Program, University of Colorado School of Medicine, Aurora, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Tollin","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, Colorado"},{"name":"Neuroscience Training Program, University of Colorado School of Medicine, Aurora, Colorado"},{"name":"Department of Otolaryngology, University of Colorado School of Medicine, Aurora, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","volume-title":"ANSI S1.11-2004: American National Standard. 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