{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T18:26:57Z","timestamp":1748370417810,"version":"3.40.5"},"reference-count":86,"publisher":"American Physiological Society","issue":"1","funder":[{"name":"VA Merit Review Award","award":["PULM-024-17S"],"award-info":[{"award-number":["PULM-024-17S"]}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:p> In 1998, I was asked by the American Physiological Society to review a book written by Dr. Michael de Burgh Daly, Peripheral Arterial Chemoreceptors and Respiratory-Cardiovascular Integration. Inspired by this work, I came to appreciate how researchers in the later stages of their careers and who provide a detailed review of their experimental approach might effectively contribute to science, especially to the benefit of young scientists (Yu J. The Physiologist 41: 231, 1998.). This article is written in that vein. Over several decades of intensive investigation of cardiopulmonary reflexes, focused on the sensory receptors, my colleagues and I advanced a novel multiple-sensor theory (MST) to explain the role of the vagal mechanosensory system. Described here is our research journey through various stages of developing MST and the process of how the problem was identified, approached, and tackled. MST redefines conventional mechanosensor doctrines and is supported by new studies that clarify a century of research data. It entails reinterpretation of many established findings. Hopefully, this article will benefit young scientists, such as graduate and postdoctoral students in the cardiopulmonary sensory research field. <\/jats:p>","DOI":"10.1152\/jn.00062.2023","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T12:01:06Z","timestamp":1687348866000},"page":"128-138","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Research journey into multiple-sensor theory"],"prefix":"10.1152","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6236-2336","authenticated-orcid":false,"given":"Jerry","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine, University of Louisville, Louisville, Kentucky, United States"},{"name":"Robley Rex VA Medical Center, Louisville, Kentucky, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","first-page":"395","volume-title":"Handbook of Physiology","author":"Coleridge HM","year":"1986"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1973.53.1.159"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.43.030181.000445"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1982.62.2.531"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(00)00201-2"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-91534-2.00014-X"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2004.12.007"},{"key":"B8","first-page":"37","volume":"32","author":"Fu XW","year":"1980","journal-title":"Acta Physiol Sinica"},{"key":"B9","first-page":"264","volume":"35","author":"Sun XY","year":"1983","journal-title":"Acta Physiol Sinica"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.42.030180.002213"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.48.5.676"},{"key":"B12","unstructured":"Yu J. Afferent Properties and Physiological Functions of Pulmonary Rapidly Adapting Receptors (PhD thesis). San Francisco, CA: University of California, 1987."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(87)80003-8"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1991.71.2.425"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.67.2.682"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(86)90058-7"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199008000-00014"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(93)90093-P"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1159\/000158893"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1996.271.5.H1912"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(99)00056-0"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)70037-X"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1990.258.4.H939"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(90)90010-V"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.80.1.233"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2020.103595"},{"key":"B27","first-page":"451","volume":"54","author":"Yu J","year":"2002","journal-title":"Sheng Li Xue Bao"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00161.2006"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.4.1485"},{"key":"B30","first-page":"270","volume":"48","author":"Yu J","year":"2000","journal-title":"J Investig Med"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.90.3.857"},{"key":"B32","first-page":"55","volume-title":"Recent Research Developments in Respiratory and Critical Care Medicine","author":"Yu J","year":"2002"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1378\/chest.116.5.1365"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1113\/EP089261"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2011.09.014"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00582.2002"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00584.2002"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.08.035"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00013.2009"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2006.036673"},{"key":"B41","first-page":"141","volume":"59","author":"Lin S-X","year":"2007","journal-title":"Sheng Li Xue Bao"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2011.058263"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2006.11.005"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1007\/978-90-481-2259-2_48"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.279.6.R2142"},{"key":"B46","first-page":"390","volume":"54","author":"Wang Y-F","year":"2002","journal-title":"Sheng Li Xue Bao"},{"key":"B47","first-page":"81","volume-title":"Handbook of Sensory Physiology","author":"Fillenz M","year":"1971"},{"key":"B48","doi-asserted-by":"crossref","first-page":"A453","DOI":"10.1096\/fj.02-0211hyp","volume":"16","author":"Wang Y","year":"2002","journal-title":"FASEB J"},{"key":"B49","first-page":"119","volume":"56","author":"Wang Y-F","year":"2004","journal-title":"Sheng Li Xue Bao"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00137.2003"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2004.07.022"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1007\/0-387-31311-7_46"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01241.2006"},{"key":"B54","first-page":"191","volume":"62","author":"Liang Y-J","year":"2010","journal-title":"Sheng Li Xue Bao"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1672-8467.2012.02.002"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.4137\/ccrpm.s547"},{"key":"B57","first-page":"1","volume":"2","author":"Moldoveanu B","year":"2009","journal-title":"J Inflamm Res"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2014.01.002"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/srep13419"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.15761\/PCCM.1000138"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.01.047"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01286.2006"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00125.2013"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00136.2020"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1159\/000364947"},{"key":"B66","first-page":"689","volume":"57","author":"Winner E","year":"2005","journal-title":"Sheng Li Xue Bao"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00116.2021"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00588"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15069"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-02563-x"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.1044577"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c130020"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00903.2015"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00064.2019"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2015.07.015"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.3.9809085"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-9077-1_26"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2023.104071"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00208.2014"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1974.sp010601"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1981.50.1.45"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1983.54.4.997"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.60.6.2048"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/S1055-937X(97)80002-3"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c100045"},{"key":"B86","volume":"41","author":"Yu J","year":"1998","journal-title":"The Physiologist"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/jn.00062.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T17:33:03Z","timestamp":1688578383000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/jn.00062.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,1]]},"references-count":86,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,7,1]]}},"alternative-id":["10.1152\/jn.00062.2023"],"URL":"https:\/\/doi.org\/10.1152\/jn.00062.2023","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"type":"print","value":"0022-3077"},{"type":"electronic","value":"1522-1598"}],"subject":[],"published":{"date-parts":[[2023,7,1]]},"assertion":[{"value":"2023-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-05","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}