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Acute pain in corporal structures is associated with the spinothalamic tract (STT), which originates in the dorsal horn of the spinal cord, whereas that associated with cranial structures is associated with the spinal division of the trigeminal nucleus. These pathways terminate in the ventral posterior nucleus (VP), including its posterior and inferior subnuclei and its core, which is classically associated with tactile and haptic functions. In medial nuclei (medial dorsal and intralaminar) receptive fields are large and stimulation evokes diffuse unpleasant sensations and pain while neurons in these nuclei subserve cognitive processes of attention, alerting, and conditioning. In the lateral nuclei neurons have small receptive and projected fields and high resolution of responses to somatic stimuli. Neurons in the lateral nuclei respond to stimuli producing pain, temperature, and visceral sensations while stimulation evokes similar sensations. Small strokes in VP core versus structures located inferior and posterior are associated with thalamic pain and decreased tactile, painful, and cold sensations and with decreased evoked potentials for painful (laser) heat and median nerve stimulation (electrical). Lesions of VP, but not ventral medial posterior nucleus (VMpo), are associated with thalamic pain, contrary to the recent \u201cdisinhibition\u201d model. We review the evidence that the lateral nuclei are associated with multiple processes including tactile, nociceptive, visceral, and thermal content of stimuli, whereas the medial nuclei are related to cognitions about those stimuli. <\/jats:p>","DOI":"10.1152\/jn.00065.2024","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T15:00:28Z","timestamp":1729090828000},"page":"1756-1778","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Neuroscience of the human thalamus related to acute pain and chronic \u201cthalamic\u201d pain"],"prefix":"10.1152","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1511-6850","authenticated-orcid":false,"given":"Fred A.","family":"Lenz","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University, Baltimore, Maryland, United 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