{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:09:41Z","timestamp":1792591781193,"version":"4.5.0"},"reference-count":98,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P01GM118269"],"award-info":[{"award-number":["P01GM118269"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01GM104948"],"award-info":[{"award-number":["R01GM104948"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005851","name":"John Simon Guggenheim Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005851","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005294","name":"Massachusetts General Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005294","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000121","name":"NSF | MPS | Division of Mathematical Sciences","doi-asserted-by":"publisher","award":["1042134-5"],"award-info":[{"award-number":["1042134-5"]}],"id":[{"id":"10.13039\/100000121","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:p>GABAergic anesthetics induce alpha\/low-beta and slow oscillations in the EEG, which interact in dose-dependent ways. We constructed a thalamocortical model to investigate how these interdependent oscillations change with propofol dose. We find two dynamic states of thalamocortical coordination, which change on the timescale of seconds and dose-dependently mirror known changes in EEG. Thalamocortical feedback determines the oscillatory coupling and power seen in each state, and this is primarily driven by cortical synchrony and brain stem neuromodulation.<\/jats:p>","DOI":"10.1152\/jn.00068.2022","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T08:00:12Z","timestamp":1686729612000},"page":"86-103","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Rapid thalamocortical network switching mediated by cortical synchronization underlies propofol-induced EEG signatures: a biophysical model"],"prefix":"10.1152","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1680-6936","authenticated-orcid":false,"given":"Austin E.","family":"Soplata","sequence":"first","affiliation":[{"name":"Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States"},{"name":"Department of Mathematics and Statistics, Boston University, Boston, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6185-1998","authenticated-orcid":false,"given":"Elie","family":"Adam","sequence":"additional","affiliation":[{"name":"Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States"},{"name":"Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2668-7819","authenticated-orcid":false,"given":"Emery N.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States"},{"name":"Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States"},{"name":"Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States"},{"name":"Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick L.","family":"Purdon","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics, Boston University, Boston, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8568-8750","authenticated-orcid":false,"given":"Nancy","family":"Kopell","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics, Boston University, Boston, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-060909-153200"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1210907109"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1221180110"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5813-12.2014"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002192"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz169"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-68756-y"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aex170"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0808281"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005879"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00845.2002"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fncom.2012.00064"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5670-12.2013"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1017069108"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.copsyc.2019.03.015"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.copsyc.2018.11.001"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1097\/ANA.0000000000000733"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000005361"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1996.76.3.2049"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(96)83006-5"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/79848"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/10.12.1185"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-19-08691.2002"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00012.2003"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00915.2004"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2445"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1098\/rsta.2011.0126"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fncom.2013.00003"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00983.2004"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3231-12.2012"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.18607"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04587.x"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.091801"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1153-05.2005"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3536-08.2008"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.04.024"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00256.2012"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80380-3"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-8993(00)02766-9"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00663-2"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810062106"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1002\/neu.10109"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(92)90012-4"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1215385109"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1177\/155005940904000305"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2018.00010"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2014.2311996"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1700148114"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.60824"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1121461109"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/80.5.644"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-013-1589-5"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200009000-00020"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000003696"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.559077"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1715841115"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2219-21.2022"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1917251117"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3137"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2207831120"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1023\/a:1026539805445"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2022.119325"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1332-21.2022"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1126\/science.1824881"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5580-10.2011"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.3389\/fncom.2014.00036"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3389\/fncom.2016.00087"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2022.905837"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.887981"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1989.61.2.233"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000003668"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06164.x"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0544-17.2017"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000003087"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2016.03.021"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000005387"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-11-04286.2000"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5088-11.2012"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2017.05.009"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1038\/nature04286"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aav3801"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aev213"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(02)00060-X"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3200"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.01.005"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197704000-00005"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1017041108"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006007"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-15082-5"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001353"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.116627"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2007.02.001"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.12871\/000398292015238"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1177\/1073858413478490"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.01.024"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.03.032"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12453"},{"key":"B100","volume-title":"Rhythms of the Brain","author":"Buzs\u00e1ki G","year":"2009"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/jn.00068.2022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T16:54:48Z","timestamp":1688057688000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/jn.00068.2022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,1]]},"references-count":98,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,7,1]]}},"alternative-id":["10.1152\/jn.00068.2022"],"URL":"https:\/\/doi.org\/10.1152\/jn.00068.2022","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.02.17.480766","asserted-by":"object"}]},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,1]]},"assertion":[{"value":"2022-02-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-08","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}