{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:05:54Z","timestamp":1791273954137,"version":"4.1.0"},"reference-count":44,"publisher":"American Physiological Society","issue":"3","funder":[{"name":"National Science Foundation","award":["IOS-0641433"],"award-info":[{"award-number":["IOS-0641433"]}]},{"name":"Chenery Endowment"},{"name":"Rashkind Endowment"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p> Like other biological systems, olfaction responds \u201chomeostatically\u201d to enduring change in the stimulus environment. This adaptive mechanism, referred to as compensatory plasticity, has been studied almost exclusively in developing animals. Thus it is unknown if this phenomenon is limited to ontogenesis and irreversible, characteristics common to some other forms of plasticity. Here we explore the effects of odor deprivation on the adult mouse olfactory epithelium (OE) using nasal plugs to eliminate nasal airflow unilaterally. Plugs were in place for 2\u20136 wk after which electroolfactograms (EOGs) were recorded from the occluded and open sides of the nasal cavity. Mean EOG amplitudes were significantly greater on the occluded than on the open side. The duration of plugging did not affect the results, suggesting that maximal compensation occurs within 2 wk or less. The magnitude of the EOG difference between the open and occluded side in plugged mice was comparable to adults that had undergone surgical naris occlusion as neonates. When plugs were removed after 4 wk followed by 2 wk of recovery, mean EOG amplitudes were not significantly different between the always-open and previously plugged sides of the nasal cavity suggesting that this form of plasticity is reversible. Taken together, these results suggest that compensatory plasticity is a constitutive mechanism of olfactory receptor neurons that allows these cells to recalibrate their stimulus-response relationship to fit the statistics of their current odor environment. <\/jats:p>","DOI":"10.1152\/jn.00076.2015","type":"journal-article","created":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T02:39:54Z","timestamp":1439433594000},"page":"2023-2032","source":"Crossref","is-referenced-by-count":15,"title":["Compensatory plasticity in the olfactory epithelium: age, timing, and reversibility"],"prefix":"10.1152","volume":"114","author":[{"given":"Casey N.","family":"Barber","sequence":"first","affiliation":[{"name":"Department of Biology, Randolph-Macon College, Ashland, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Coppola","sequence":"additional","affiliation":[{"name":"Department of Biology, Randolph-Macon College, Ashland, 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